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Member Research & Reports

Member Research & Reports

BU: Ejaculation Changes Prostate Tissue, Lowering Cancer Risk

Higher frequency of ejaculation is associated with lower risk of prostate cancer, as a previous study led by a Boston University School of Public Health (BUSPH) researcher confirmed. Now, Dr. Jennifer R. Rider, BUSPH assistant professor of epidemiology, and her colleagues have found a clue as to why, identifying molecular-level changes in prostate tissue.

The study, published in European Urology, finds evidence that more frequent ejaculation affects the expression of 409 genes and six biological processes. The study may support the “prostate stagnation hypothesis,” where carcinogens accumulate in the prostate between ejaculations and affect cells’ genome and metabolic processes.

The researchers used data from participants in the Health Professionals Follow-Up Study (HPFS), looking at 157 participants who were diagnosed with prostate cancer between 1992 and 2004 and subsequently had part or all of their prostates removed. The researchers analyzed 20,254 genes in the samples, and found significant associations in the expression of 409 genes when they looked at self-reported ejaculation frequency in 1991. Next, focusing on ejaculation frequency in 1991, the researchers found associations with six different biological processes at the cellular level. The most significant association was with ubiquitin-mediated proteolysis, which is involved in cell cycle regulation. The researchers also noted an association between higher rates of ejaculation and cells producing and exporting more citrate, a component of semen, because lower citrate production is a distinguishing feature of prostate cancer.

“These molecular changes in the prostate persist for many years,” says Dr. Rider, who served as senior author on the study. “Understanding the biological links between ejaculation and prostate tumor development could lead to new behavioral or medical strategies for prevention.”

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