People who experience atrial fibrillation (AF), a heart arrhythmia, may also have a smaller brain—specifically, reduced frontal lobe volume—according to research led by Boston University School of Public Health (BUSPH) faculty.
AF is a serious cardiovascular condition that is associated with an increased risk of stroke, heart failure, and death, as well as cognitive decline and increased risk of dementia. But little is known about the impact of AF on brain structure in people whose cognition is intact.
The new study, which appears in the journal Heart Rhythm, looks at the relationship between AF and brain volume, as measured by magnetic resonance imaging (MRI). The researchers examined total cerebral volume, frontal lobe volume, temporal lobe volume, hippocampal volume and white matter hyper-intensity volume in patients without prior stroke or dementia. Their results showed that AF was associated with smaller frontal lobe volumes, even after adjusting for age, gender, vascular risk factors, and APOE4 (a gene independently linked to smaller brain volumes).
“We believe that good heart health also contributes to good brain health, and given that the incidence of AF is expected to more than double in the next three decades, we are interested in understanding the association between AF and brain anatomy,” said corresponding author Dr. Rhoda Au, professor of epidemiology and neurology at BUSPH and director of neuropsychology for the Framingham Heart Study.
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