Children exposed during pregnancy to elevated levels of two common chemicals found in the home—di-n-butyl phthalate (DnBP) and di-isobutyl phthalate (DiBP)—had an IQ score, on average, more than six points lower than children exposed at lower levels, according to researchers at Columbia University’s Mailman School of Public Health. The study is the first to report a link between prenatal exposure to phthalates and IQ in school-age children. Results appear online in the journal PLOS ONE.
DnBP and DiBP are found in a wide variety of consumer products, from dryer sheets to vinyl fabrics to personal care products like lipstick, hairspray, and nail polish, even some soaps. Since 2009, several phthalates have been banned from children’s toys and other childcare articles in the United States. However, no steps have been taken to protect the developing fetus by alerting pregnant women to potential exposures. In the U.S., phthalates are rarely listed as ingredients on products in which they are used
Researchers followed 328 New York City women and their children from low-income communities. They assessed the women’s exposure to four phthalates — DnBP, DiBP, di-2-ethylhexyl phthalate, and diethyl phthalate — in the third trimester of pregnancy by measuring levels of the chemicals’ metabolites in urine. Children were given IQ tests at age 7.
Children of mothers exposed during pregnancy to the highest 25 percent of concentrations of DnBP and DiBP had IQs 6.6 and 7.6 points lower, respectively, than children of mothers exposed to the lowest 25 percent of concentrations after controlling for factors like maternal IQ, maternal education, and quality of the home environment that are known to influence child IQ scores. The association was also seen for specific aspects of IQ, such as perceptual reasoning, working memory, and processing speed. The researchers found no associations between the other two phthalates and child IQ.
The range of phthalate metabolite exposures measured in the mothers was not unusual: it was within what the Centers for Disease Control and Prevention observed in a national sample.
“Pregnant women across the United States are exposed to phthalates almost daily, many at levels similar to those that we found were associated with substantial reductions in the IQ of children,” says lead author Dr. Pam Factor-Litvak, associate professor of Epidemiology at the Mailman School.
“The magnitude of these IQ differences is troubling,” says senior author Dr. Robin Whyatt, professor of environmental health sciences and deputy director of the Columbia Center for Children’s Environmental Health at the Mailman School. “A six- or seven-point decline in IQ may have substantial consequences for academic achievement and occupational potential.”
“While there has been some regulation to ban phthalates from toys of young children,” adds Dr. Factor-Litvak, “there is no legislation governing exposure during pregnancy, which is likely the most sensitive period for brain development. Indeed, phthalates are not required to be on product labeling.”