Dr. Mary Schooling, professor at the CUNY Graduate School of Public Health and Health Policy and an international team of investigators examined the association of endogenous testosterone with cognitive function among older men. The findings were published in Scientific Reports.
Testosterone replacement for older men is increasingly common, with some observations suggesting a protective effect on cognitive function. This team of researchers used a Mendelian randomization study to examine the association of endogenous testosterone with cognitive function among older men.
A genetic score predicting testosterone was developed in 289 young Chinese men from Hong Kong based on selected testosterone-related single nucleotide polymorphisms. The researchers used 4,212 older Chinese men from the Guangzhou Biobank Cohort Study. At both baseline and follow-up, the research team assessed the association of genetically predicted testosterone with delayed 10-word recall score and Mini-Mental State Examination. Predicted testosterone was not associated with either delayed 10-word recall score or Mini-Mental State Examination score. The estimates were similar after additional adjustment for age, education, smoking, use of alcohol, body mass index, and the Framingham score. This team’s findings did not corroborate observed protective effects of testosterone on cognitive function among older men.