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Member Research and Reports

Member Research and Reports

CUNY Reports That Testosterone May Increase Cardiovascular Risk

Testosterone in men declines with age and ill-health, so low testosterone tends to correlate with cardiovascular disease risk factors, cardiovascular disease, and mortality. Testosterone replacement is increasingly promoted to older men, although the safety of testosterone replacement has never been assessed in a large trial. Meta-analyses of small, randomized-controlled trials suggest testosterone administration lowers HDL-cholesterol and increases the risk of cardiovascular-related events. To clarify the role of testosterone without any potentially harmful interventions, CUNY School of Public Health researchers compared cardiovascular disease risk factors among men by genetically determined levels of testosterone using an innovative study design, i.e., a separate-sample Mendelian randomization study.