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DHHS Funding Opportunities

FUNDING OPPORTUNITIES from the Department of Health and Human Services (DHHS)

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Department of Health and Human Services – Office of the Assistant Secretary for Health – Advancing Health Literacy to Enhance Equitable Community Responses to COVID-19

Proposal Due Date: April 20, 2021

Expected Number of Awards: 73

Estimated Total Program Funding:

Award Ceiling: $4,000,000

Award Floor: $3,000,000

Funding Opportunity Number: MP-CPI-21-006

Purpose: The Office of the Assistant Secretary for Health (OASH) and the Office of Minority Health (OMH) announce the availability of funds for Fiscal Year (FY) 2021 under the authority of 42 U.S.C. § 300u-6 (Section 1707 of the Public Health Service Act) and the Coronavirus Response and Relief Supplemental Appropriations Act, 2021 (P.L. 116-260). OMH is dedicated to improving the health of racial and ethnic minority populations through the development of health policies and programs that will help eliminate health disparities. Through its demonstration grants, OMH supports the identification of effective approaches for improving health outcomes with the ultimate goal of promoting dissemination, adoption and sustainability of these approaches. The Advancing Health Literacy to Enhance Equitable Community Responses to COVID-19 initiative aligns with: (1) HHS Strategic Plan Goal 2: Protect the Health of Americans Where They Live, Learn, Work, and Play; (2) Healthy People 2030 objectives: (a) HC/HIT-01: Increase the proportion of adults whose health care provider checked their understanding; (b) HC/HIT-02: Reduce the proportion of adults who report poor patient and provider communication; (c) HC/HIT-03: Increase the proportion of adults whose health care providers involved them in decisions as much as they wanted; and (d) IID-D02: Increase the proportion of people with vaccination records in an information system; and (3) the OASH priority on health disparities (1, 2). OMH will consider the following additional factors when making recommendations for funding, listed below in no particular order:

https://www.grants.gov/web/grants/view-opportunity.html?oppId=330807

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Department of Health and Human Services – Administration for Community Living – Disability and Rehabilitation Research Projects (DRRP) Program: National Research Center for Parents with Disabilities

Proposal Due Date: May 7, 2021

Expected Number of Awards: 1

Estimated Total Program Funding: $500,000

Award Ceiling: $500,000

Award Floor: $495,000

Funding Opportunity Number: HHS-2021-ACL-NIDILRR-DPCP-0060

Purpose: The purpose of NIDILRR’s Disability and Rehabilitation Research Projects (DRRP) which are funded through the Disability and Rehabilitation Research Projects and Centers Program, is to plan and conduct research, demonstration projects, training, and related activities, including international activities, to develop methods, procedures, and rehabilitation technology that maximize the full inclusion and integration into society, employment, independent living, family support, and economic and social self-sufficiency of individuals with disabilities, especially individuals with the most severe disabilities, and to improve the effectiveness of services authorized under the Rehabilitation Act of 1973, as amended (Rehabilitation Act). Under this particular DRRP priority, the Center must conduct research and related activities toward services, technologies, and other interventions to support parents with disabilities in their parenting roles.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=330451

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Department of Health and Human Services – Administration for Community Living –
Spinal Cord Injury Model Systems

Proposal Due Date: May 8, 2021

Expected Number of Awards: 14

Estimated Total Program Funding: $6,500,000

Award Ceiling: $490,000

Award Floor: $440,000

Funding Opportunity Number: HHS-2021-ACL-NIDILRR-SIMS-0049

Purpose: The SCIMS program is designed to provide research-based knowledge to support a multidisciplinary system of rehabilitation care specifically to meet the needs of individuals with SCI. To be eligible for a SCI Model Systems grant, an applicant institution must provide a continuum of care for people with SCI, including emergency medical services, acute care services, acute medical rehabilitation services, and post-acute services. For purposes of this program, SCI is defined as a clinically discernible degree of neurologic impairment of the spinal cord following a traumatic event. SCIMS Centers must conduct site-specific and collaborative research.  SCIMS Centers must also collect and contribute data to the SCIMS longitudinal database.

SCIMS Centers will be funded at varying amounts up to the maximum award based on the numbers of database participants eligible for follow-up in the SCIMS longitudinal database. Existing centers with significantly larger numbers of database participants will receive higher funding within the specified range, as determined by NIDILRR after the applicants are selected for funding. Funding will be determined individually for each successful applicant, up to the maximum allowed, based upon the documented workload associated with the follow-up data collection, the other costs of the grant, and the overall budgetary limits of the program.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=330347

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Department of Health and Human Services – Administration for Community Living – Disability and rehabilitation research projects (DRRP) program: disability and pregnancy

Proposal Due Date: May 11, 2021

Expected Number of Awards: 1

Estimated Total Program Funding: $500,000

Award Ceiling: $500,000

Award Floor: $495,000

Funding Opportunity Number: HHS-2021-ACL-NIDILRR-DPHF-0059

Purpose: The purpose of NIDILRR’s Disability and Rehabilitation Research Projects (DRRP) which are funded through the Disability and Rehabilitation Research Projects and Centers Program, is to plan and conduct research, demonstration projects, training, and related activities, including international activities, to develop methods, procedures, and rehabilitation technology that maximize the full inclusion and integration into society, employment, independent living, family support, and economic and social self-sufficiency of individuals with disabilities, especially individuals with the most severe disabilities, and to improve the effectiveness of services authorized under the Rehabilitation Act of 1973, as amended (Rehabilitation Act).

https://www.grants.gov/web/grants/view-opportunity.html?oppId=330453

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Department of Health and Human Services – Administration for Community Living – Disability and Rehabilitation Research Projects (DRRP) Program: Model Systems Knowledge Translation Center (MSKTC)

Proposal Due Date: May 11, 2021

Expected Number of Awards: 1

Estimated Total Program Funding: $792,000

Award Ceiling: $5792,000

Award Floor: $787,000

Funding Opportunity Number: HHS-2021-ACL-NIDILRR-DPKT-0062

Purpose: The purpose of NIDILRR’s DRRPs, which are funded through the Disability and Rehabilitation Research Projects and Centers Program, is to improve the effectiveness of services authorized under the Rehabilitation Act by developing methods, procedures, and rehabilitation technologies that advance a wide range of independent living and employment outcomes for individuals with disabilities, especially individuals with the most significant disabilities. Under this particular opportunity, a DRRP must conduct knowledge translation and related activities in collaboration with the Burn Model System, Spinal Cord Injury (SCI) Model System, and Traumatic Brain Injury (TBI) Model System grantees. Specifically, the MSKTC will be required to collaborate with the model system centers to produce systematic reviews of existing research and information products for SCI, TBI, and Burn; identify effective strategies for disseminating those products and SCI, TBI, and Burn Model System programs’ research findings; serve as the central resource for product dissemination; and provide training and technical assistance in knowledge translation for the Model System grantees.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=330447

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Department of Health and Human Services – Centers for Disease Control and Prevention – NCIRD – Partnering with National Organizations to Support Community-Based Organizations to Increase Vaccination Coverage Across Different Racial and Ethnic Adult Populations Currently Experiencing Disparities

Proposal Due Date: March 29, 2021

Expected Number of Awards: 4

Estimated Total Program Funding: $40,000,000

Award Ceiling:

Award Floor:

Funding Opportunity Number: CDC-RFA-IP21-2108

Purpose: CDC seeks to build the evidence base of effective interventions to improve vaccination coverage and identify and implement strategies to reduce racial and/or ethnic disparities in adult vaccination coverage.

This NOFO’s goal is to support efforts to increase flu and COVID-19 vaccination coverage for adults in racial and/or ethnic populations experiencing disparities in the United States. This NOFO has three parts. All national recipients are responsible for Part A activities and are expected to monitor, evaluate, and support community-based organizations’ (CBOs) implementations of Part C activities. Only 1-2 national recipients will also implement Part B activities.

Partnering with national organizations to fund CBOs will help expedite CDC’s ability to address vaccination disparities in communities of color. Due to the need for local outreach, CBOs are the ideal messengers—however, the federal granting process could prove to be a significant barrier for many small, specialized CBOs with strong community ties to participate in the funding program. This program strategy enables CDC’s funding to have an impact in hundreds of communities across the nation and enhances ISD’s capacity to build trust and amplify messages in these communities.

The proposed strategy for CDC to fund organizations at the community level includes funding four national organizations to subgrant to more than 200 community-based organizations (CBO) with strong ties to racial and ethnic minority communities as well as supporting these national partners’ efforts to provide CBOs with technical assistance and access to materials.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=332136

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Department of Health and Human Services – Centers for Disease Control and Prevention – ERA – Rigorously Evaluating Programs and Policies to Prevent Child Sexual Abuse (CSA)

Proposal Due Date: May 10, 2021

Expected Number of Awards: 3

Estimated Total Program Funding: $4,800,000

Award Ceiling: $400,000

Award Floor: $0

Funding Opportunity Number: RFA-CE-21-006

Purpose: The Centers for Disease Control and Prevention’s National Center for Injury Prevention and Control (NCIPC) is soliciting investigator-initiated research proposals to rigorously evaluate approaches (programs, policies, or practices) for their impact on primary prevention of child sexual abuse (CSA) perpetrated by youth or adults. Research funded under this announcement will strengthen the evidence base for primary prevention of youth- or adult-perpetrated CSA. Applicants must propose rigorous evaluation designs, which for the purposes of this funding opportunity can include those that utilize experimental designs (i.e., randomized controlled trials) or quasi-experimental designs (e.g., comparative interrupted time series design, difference-in- differences, instrumental variables, regression discontinuity, regression point displacement, stepped wedge, propensity-score matching, comparison groups).

https://www.grants.gov/web/grants/view-opportunity.html?oppId=331456

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Department of Health and Human Services – Centers for Disease Control – NCIPC –
Drug-Free Communities (DFC) Support Program

Proposal Due Date: May 10, 2021

Expected Number of Awards: 100

Estimated Total Program Funding: $62,500,000

Award Ceiling: $125,000

Award Floor: $0

Funding Opportunity Number: CDC-RFA-CE21-2102

Purpose: The Drug-Free Communities (DFC) Support Program was created by the Drug-Free Communities Act of 1997 (Public Law 105-20). The Executive Office of the President, Office of National Drug Control Policy (ONDCP), and the Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC), National Center for Injury Prevention and Control (NCIPC) are accepting applications for Fiscal Year (FY) 2021 Drug-Free Communities (DFC) Support Program grants. The purpose of CDC-RFA-CE21-2102 is to fund applicants who have never received DFC funding to carry out the two goals of the DFC program.  By statute, the DFC Support Program has two goals:

1) Establish and strengthen collaboration among communities, public and private non-profit agencies, as well as federal, state, local, and tribal governments to support the efforts of community coalitions working to prevent and reduce substance abuse among youth (individuals 18 years of age and younger).

2) Reduce substance abuse among youth and, over time, reduce substance abuse among adults by addressing the factors in a community that increase the risk of substance abuse and promoting the factors that minimize the risk of substance abuse.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=330868

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Department of Health and Human Services – Centers for Disease Control – NCEZID –
Strengthening Rocky Mountain spotted fever (RMSF) prevention and control in Arizona tribal lands

Proposal Due Date: May 14, 2021

Expected Number of Awards: 6

Estimated Total Program Funding: $1,800,000

Award Ceiling: $350,000

Award Floor: $10,000

Funding Opportunity Number: CDC-RFA-CK21-2102

Purpose: Rocky Mountain spotted fever (RMSF) occurs in epidemic proportions in parts of Arizona tribal lands. Annual incidence of RMSF in certain tribal communities is more the 150 times higher than the national average, and more than 50% of RMSF cases occur in children. Prevention of RMSF require collaboration of human, animal, and environmental health partners. The purpose of this NOFO is to provide resources to American Indian tribal nations impacted by Rocky Mountain spotted fever in Arizona. These resources will support the development and maintenance of RMSF prevention and control programs within their communities by increasing use of evidence-based interventions, developing improved communications products, strengthening RMSF support services like animal control and vector control services within the community, enhancing tracking of key progress indicators, and by providing support to evaluate the use of current RMSF prevention programs. Through this FOA, CDC seeks to fund eligible federally recognized tribes to provide capacity building in strengthening tribal health systems, and evaluate and monitor awarded tribal public health capacity building projects in AI/AN communities.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=330382

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Department of Health and Human Services – Centers for Disease Control – OSTLTS –
Tribal Public Health Capacity-Building and Quality Improvement Umbrella Cooperative Agreement

Proposal Due Date: May 21, 2021

Expected Number of Awards: 15

Estimated Total Program Funding: $2,500,000

Award Ceiling:

Award Floor:

Funding Opportunity Number: CDC-RFA-OT18-18030401SUPP21

Purpose: CDC announces a supplemental funding opportunity for the 25 American Indian/Alaska Native (AI/AN) tribal nations and regional AI/AN tribally designated organizations that were awarded under CDC-RFA-OT18-1803: Tribal Public Health Capacity-Building and Quality Improvement Umbrella Cooperative Agreement.  The goal of this additional funding is to provide resources to optimize the quality and performance of tribal public health systems, including infrastructures, workforce, data and information systems, programs and services, resources and communication, and partnerships. Work in these areas will increase the capacity of Indian Country to identify, respond to, and mitigate public health threats and decrease burden of disease among AI/ANs. The CDC-RFA-OT18-1803 recipients are eligible to submit applications for new fiscal year (FY) 2021 Center, Institute, and Office (CIO) Project Plans according to the geographic categories under which they are awarded. The geographic categories are the following: 1) Category A: HHS Regions I, II, III, and IV; 2) Category B: HHS Regions V, VI, and VII; and 3) Category C: HHS Regions VIII, IX, and X.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=332031

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Department of Health and Human Services – Centers for Disease Control – ATSDR –
Early Detection of Certain Medical Conditions Related to Environmental Health Hazards Supplement

Proposal Due Date: June 10, 2021

Expected Number of Awards: 1

Estimated Total Program Funding: $999,999

Award Ceiling: $999,999

Award Floor: $999,999

Funding Opportunity Number: CDC-RFA-TS19-19020301SUPP21

Purpose: Libby, Montana was the site of a vermiculite mining and processing operation from the early 1920’s through 1990. While it was in operation, Libby was the world’s largest source of vermiculite. The commercial uses of vermiculite include insulation, fire proofing, and as a soil conditioner. Unfortunately, Libby vermiculite is contaminated with amphibole asbestos. This has resulted in asbestos-related morbidity and mortality in vermiculite workers, their family members, and residents with neither occupational nor para-occupational exposure.

Reports of pervasive asbestos-related health outcomes in Libby prompted a concerted response by the federal government in 1999. A large component of this response was community-based screening conducted by the Agency for Toxic Substances and Disease Registry (ATSDR) in 2000 and 2001 in which 7,307 persons were screened. Additional screening was funded by ATSDR via a grant to the Montana Department of Health and Human Services 2003-2008 and to the Lincoln County Health Department 2009-2011. Libby was subsequently declared and environmental public health emergency and language was included in the Affordable Care Act (ACA, Public Law 111-148; https://www.hhs.gov/sites/default/files/ppacacon.pdf) to continue to make screening available to persons with potential past exposure to vermiculite while they resided in the Libby area. Persons with positive screening results may be eligible for Medicare benefits.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=332008

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Department of Health and Human Services – Centers for Medicare & Medicaid Services – Emergency Triage, treat, and transport (ET3) Model

Proposal Due Date: May 11, 2021

Expected Number of Awards: 40

Estimated Total Program Funding: $0

Award Ceiling: $1,175,000

Award Floor: $0

Funding Opportunity Number: CMS-2F2-21-001

Purpose: The Emergency Triage, Treat, and Transport (ET3) model (the “model”) is a voluntary, five-year payment model that will provide greater flexibility to ambulance care teams to address emergency health care needs of Medicare Fee-for-Service (FFS) beneficiaries following a 911 Call. ET3 consists of three interventions: the treatment in place and transport to an alternative destination interventions described in the Request for Applications, and the triage intervention described in this Notice of Funding Opportunity (NOFO). Together, these interventions make up a comprehensive model for potentially improving the quality of care and lowering costs to Medicare by reducing avoidable transports to hospital emergency departments (EDs) and avoidable inpatient admissions.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=326039

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Department of Health and Human Services – Food and Drug Administration – Expanding the opioids system modelling efforts to more comprehensively address fentanyl, stimulants use, polysubstance use and associated outcomes (U10 clinical trials not allowed)

Proposal Due Date: May 17, 2021

Expected Number of Awards: 1

Estimated Total Program Funding:

Award Ceiling: $1,250,000

Award Floor: $250,000

Funding Opportunity Number: RFA-FD-21-022

Purpose: The purpose of this funding opportunity is to expand on the FDA’s modeling efforts to more comprehensively address fentanyl, stimulants and polysubstance use and their interactive effects on opioids use, misuse, use disorder, addiction treatment, and associated outcomes. The primary purpose of this project is to capture the dynamics of and interactions between stimulant or polysubstance use and opioid overdose deaths, as an important emerging aspect of the opioids crisis. The research should also seek to quantify how polysubstance use and synthetic opioids may influence the effects of harm reduction approaches and other potential overdose-prevention strategies. A secondary purpose of the research is to identify and implement feasible approaches for incorporating mental health into part of FDA’s modeling effort.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=332074

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Department of Health and Human Services – Food and Drug Administration – Enhancing Innovations in Advanced Manufacturing Technologies for Vaccines against Influenza and Emerging Infectious Diseases (R01) Clinical Trials Not Allowed

Proposal Due Date: May 18, 2021

Expected Number of Awards: 4

Estimated Total Program Funding: $2,000,000

Award Ceiling: $500,000

Award Floor:

Funding Opportunity Number: RFA-FD-21-033

Purpose: CBER seeks to support several research projects that are focused on developing novel technologies for the advanced manufacturing of complex biologic products or innovative analytical approaches for improving product manufacturing and quality.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=332098

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Department of Health and Human Services – Health Resources and Services Administration – Quality Improvement Solutions for Sustained Epidemic Control Project (QISSEC)

Proposal Due Date: May 7, 2021

Expected Number of Awards: 2

Estimated Total Program Funding: $20,000,000

Award Ceiling: $0

Award Floor: $0

Funding Opportunity Number: HRSA-21-096

Purpose: This notice announces the opportunity to apply for funding for the Quality Improvement Solutions for Sustained Epidemic Control Project (QISSEC). The purpose of this project is to facilitate improvements in quality across the HIV care continuum at the site level (defined as the location where persons diagnosed with HIV receive care and treatment) and within the community. The project attempts to improve the effectiveness, efficiency, patient-centeredness, safety, accessibility, and equity of the HIV services in low to middle-income countries (LMIC) as identified by the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR) program. FY21 PEPFAR priorities recognize quality health services as essential in order to ensure that optimal health outcomes are met on a daily and routine basis. Therefore, all PEPFAR country programs must incorporate explicit quality management (QM) practices, including both quality assurance (QA) and quality improvement (QI) activities into service delivery and partner management. Focused on building the capacity of countries to sustain and spread QI methodologies, improve documentation of efforts, and continuously enhance staff knowledge, QISSEC strives to impact the delivery of quality HIV services, improve health outcomes, and support HIV/AIDS epidemic control. This Notice of Funding Opportunity (NOFO) will fund two cooperative agreements in support of the PEPFAR focus on the management of evidence-informed interventions for scale-up and spread. The successful applicants will facilitate solutions for long-term change management approaches and sustainability of QA and QI activity. The QISSEC shall focus on developing innovative strategies to improve the delivery of HIV quality care and treatment for use by facilities that serve the most vulnerable individuals in PEPFAR-supported LMICs. Using quality improvement methodologies, tools, and techniques, the project will identify gaps in service delivery, and develop culturally and medically appropriate, sustainable interventions targeted to PEPFAR- identified vulnerable and key populations. Over 18 years PEPFAR https://www.state.gov/pepfar/ has evolved to a complex and high impact program, with mature stakeholders and partners showing that epidemic control is indeed possible. It is in this context that HRSA is renewing its commitment to PEPFAR and specifically seeking to fill gaps as well as to bring targeted and innovative solutions to the remaining barriers to epidemic control around the globe. The PEPFAR 2021 Country Operational Plan Guidance for all PEPFAR Countries (https://www.state.gov/wp-content/uploads/2020/12/PEPFAR-COP21-Guidance-Final.pdf) suggests all PEPFAR country programs must incorporate explicit quality management practices, including both QA and QI activities, into service delivery and partner management.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=329951

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Department of Health and Human Services – Health Resources and Services Administration – Global Reach I

Proposal Due Date: May 10, 2021

Expected Number of Awards: 2

Estimated Total Program Funding: $20,000,000

Award Ceiling: $0

Award Floor: $0

Funding Opportunity Number: HRSA-21-066

Purpose: This notice announces the opportunity to apply for funding under the Global Reach I Program. The purpose of this initiative is to collaboratively formulate and deliver high quality solutions across the range of programming required to achieve durable HIV epidemic control, emphasizing new and innovative approaches pursued jointly with HRSA and other stakeholders. An additional purpose is to assist with translating new science into programming and to mitigate the impact of forces such as global pandemics in the HIV response. Programs and activities are to span health services, structural interventions, and data use and tracking systems. Global Reach I encompasses four major categories of support: 1. HIV Direct Service Delivery 2. Human Resources for Health 3. Quality Improvement 4. Health System Strengthening Global Reach I will also involve “reaching back” to HRSA’s broader expertise and equities, to be brought to bear on global health needs

https://www.grants.gov/web/grants/view-opportunity.html?oppId=328442

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Department of Health and Human Services – National Institutes of Health – HEAL Initiative: Planning Studies for Initial Analgesic Development Initial Translational Efforts (Small Molecules and Biologics) (R34 Clinical trial not allowed)

Letter of Intent Due Date: 30 days prior to application due date

Proposal Due Date: April 27, 2021, June 22, 2021, October 13, 2021

Expected Number of Awards:

Estimated Total Program Funding:

Award Ceiling: $500,000

Award Floor:

Funding Opportunity Number: RFA-NS-21-016

Purpose: The goal of this funding opportunity announcement (FOA) is to solicit Initial Analgesic Development R34 applications that propose 2-year exploratory/planning awards that are expected to enable a future application for RFA-NS-21-015 HEAL Initiative: Team Research – for Initial Translational Efforts in Non-addictive Analgesic Development [Small Molecules and Biologics] (U19 Clinical Trial Not Allowed). Thus, the limited scope of aims and approach of these applications are expected to establish a strong research team, feasibility, validity, or other technically qualifying results that support, enable, and/or lay the groundwork for a subsequent Team Research U19 application. These R34 awards will support the building of a research team to collect initial data and recruit additional collaborators. The proposal must include a plan for developing a strong research team, as well as a strategy to collect preliminary data linking putative therapeutic targets to the proposed pain indication and supporting the hypothesis that altering target activity will produce desirable outcomes for the disease.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=332048

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Department of Health and Human Services – National Institutes of Health – HEAL Initiative: Analgesic Development Initial Translational Efforts (Small Molecules and Biologics) (U19 Clinical trial not allowed)

Letter of Intent Due Date: 30 days prior to application due date

Proposal Due Date: April 27, 2021, June 22, 2021, October 13, 2021

Expected Number of Awards:

Estimated Total Program Funding:

Award Ceiling: $15,000,000

Award Floor:

Funding Opportunity Number: RFA-NS-21-015

Purpose: This funding opportunity announcement (FOA) is part of a suite of FOAs to support the development of safe, effective, and non-addictive therapeutics to treat pain. The goal of this FOA is to support team-based research projects to develop assays, screening and early optimization work to develop a non-addictive therapeutic to treat pain. Discovery and validation of pharmacodynamic markers efficacy and pharmacokinetic/pharmacodynamic (PK/PD) studies are also responsive. The result of the project should be to advance a hit or lead to the point where they can meet the entry criteria for RFA-NS-21-010 HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional) within the 5 years of the award, there is no opportunity for renewal of this award. Applications should propose a plan that will lead to the development of analgesics with a rigorous biological rationale and scientifically sound assays. If the data does not currently exist, the proposal must include a strong plan for developing data linking the putative therapeutic target(s) to the proposed pain indication and supporting the hypothesis that altering the target activity will produce desirable outcomes for the disease. This FOA is not specific for any one or group of pain conditions. Projects to develop therapeutics for acute pain, chronic pain, painful neuropathy, musculoskeletal pain, headache disorders, osteoarthritis, diabetic neuropathy, chemotherapy-induced neuropathy, eye pain, sickle-cell pain, post-surgical pain, cancer pain, visceral pain, post stroke pain, myofascial pain, painful disorders of the orofacial region and other conditions will be considered.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=332047

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Department of Health and Human Services – National Institute of Health – Technologies for Improving Minority Health and Eliminating Health Disparities (R41/R42 Clinical Trial Optional)

Letter of Intent Due Date: April 2, 2021

Proposal Due Date: May 3, 2021

Expected Number of Awards:

Estimated Total Program Funding:

Award Ceiling:

Award Floor:

Funding Opportunity Number: RFA-MD-21-005

Purpose: This Funding Opportunity Announcement (FOA) invites eligible United States small business concerns (SBCs) to submit Small Business Technology Transfer (STTR) grant applications that propose to develop a product, process or service for commercialization with the aim of improving minority health and/or reducing and ultimately eliminating health disparities in one or more NIH-defined populations experiencing health disparities. Appropriate technologies should be effective, affordable, and culturally acceptable.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=332061

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Department of Health and Human Services – National Institute of Health – Innovations for Healthy Living – Improving Minority Health and Eliminating Health Disparities (R43/R44 – clinical trial optional)

Letter of Intent Due Date: April 2, 2021

Proposal Due Date: May 3, 2021

Expected Number of Awards:

Estimated Total Program Funding:

Award Ceiling:

Award Floor:

Funding Opportunity Number: RFA-MD-21-006

Purpose: This Funding Opportunity Announcement (FOA) invites eligible United States small business concerns (SBCs) to submit Small Business Innovation Research (SBIR) grant applications that propose to conduct innovative research supporting the development of a product, tool, technology, process or service for commercialization with the aim of eliminating disparities in socioeconomically disadvantaged populations, underserved rural populations, and sexual and gender minority populations or improving health in racial/ethnic minority populations.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=332062

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Department of Health and Human Services – National Institutes of Health – Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of Nervous System (UG3/UH3 clinical trial optional)

Letter of Intent Due Date: 30 days prior to application due date

Proposal Due Date: May 7, 2024

Expected Number of Awards:

Estimated Total Program Funding:

Award Ceiling:

Award Floor:

Funding Opportunity Number: PAR-21-163

Purpose: The Blueprint Neurotherapeutics Network for Biologics (BPN-Biologics) provides support for biologic-based therapeutic discovery and development, from lead optimization through phase I clinical testing. This Funding Opportunity Announcement (FOA) supports preclinical discovery and development of potential therapeutic Biotechnology Products and Biologics including, but not limited to, large biologic macromolecules, (e.g., proteins, antibodies, and peptides), gene-based therapies (i.e., oligonucleotide- and viral-based), cell therapies, and novel emerging therapies (e.g., microbial and microbiome therapies). Applicants will collaborate with NIH-funded consultants and can augment their project with NIH contract research organizations (CROs) that specialize in manufacturing, scaling, pharmacokinetics, toxicology, and Phase I clinical testing. BPN-Biologics awardee institutions retain their assignment of IP rights and gain assignment of IP rights from the BPN-Biologics contractors (and thereby control the patent prosecution and licensing negotiations) for biotherapeutic candidates developed in this program.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=332045

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Department of Health and Human Services – National Institutes of Health –
Limited Competition to Convert the CNS HIV Antiretroviral Therapy Effects Research (CHARTER) Study Cohort to a Research Resource (R24 – Clinical Trial Not Allowed)

Letter of Intent Due Date: April 7, 2021

Proposal Due Date: May 10, 2021

Expected Number of Awards: 1

Estimated Total Program Funding: $1,250,000

Award Ceiling: $1,250,000

Award Floor:

Funding Opportunity Number: RFA-MH-21-170

Purpose: This Limited Competition Funding Opportunity Announcement (FOA) invites applications to continue the activities of the National NeuroAIDS Tissue Repository (NNTC), a data coordination center for the CHARTER cohort (a cohort of individuals living with HIV on Antiretroviral therapy). CHARTER research sites and DCC will continue to collect and provide research data as well as research specimens to interested investigators to address high priority research areas in NeuroHIV.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=331983

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Department of Health and Human Services – National Institutes of Health –
New Directions in Hematology Research (SHINE-II) (R01 Clinical Trial Optional)

Proposal Due Date: June 5, 2021

Expected Number of Awards:

Estimated Total Program Funding: $2,100,000

Award Ceiling: $200,000

Award Floor:

Funding Opportunity Number: PAS-21-150

Purpose: This Funding Opportunity Announcement (FOA) seeks innovative grant applications in nonmalignant hematology research that will steer the field in new directions.  Applications to this FOA should propose proof of principle research that is tightly focused into one specific aim, which can be accomplished within a 1-3 year project period, and is directed at validating novel concepts and approaches that promise to open new pathways for discovery.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=331945

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Department of Health and Human Services – National Institutes of Health –
Secondary Analyses of Existing Datasets of Tobacco Use and Health (R21 Clinical Trial Not Allowed)

Letter of Intent Due Date: 60 days prior to application due date

Proposal Due Date: October 8, 2021

Expected Number of Awards: 5

Estimated Total Program Funding: $1,000,000

Award Ceiling: $200,000

Award Floor:

Funding Opportunity Number:  RFA-OD-21-003

Purpose: The purpose of this Funding Opportunity Announcement (FOA) is to invite R21 applications proposing the innovative analysis of existing (publicly available) nationally representative U.S. cross-sectional and longitudinal data, to investigate novel scientific ideas and/or to generate new models, systems, tools, methods, or technologies that have the potential for significant impact on biomedical or biobehavioral research in areas relevant to the Food and Drug Administration (FDA) – Center for Tobacco Products (CTP). Other publicly available data sets would be considered depending on the analyses to be conducted; however, nationally representative analyses will receive priority.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=332028

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Department of Health and Human Services – National Institutes of Health –
Maximizing the Scientific Value of Existing Biospecimen Collections (R21 Clinical Trial Not Allowed)

Letter of Intent Due Date: 60 days prior to application due date

Proposal Due Date: October 8, 2021

Expected Number of Awards: 5

Estimated Total Program Funding: $1,000,000

Award Ceiling: $200,000

Award Floor:

Funding Opportunity Number:  RFA-OD-21-004

Purpose: The purpose of this Funding Opportunity Announcement (FOA) is to invite R21 applications to stimulate exploratory research relevant to the mission of the Food and Drug Administration (FDA) – Center for Tobacco Products (CTP) using existing (publicly available) biospecimens currently stored in repositories in the United States. This will include, but not be limited to, collections associated with the Population Assessment of Tobacco and Health (PATH) Study, the National Health and Nutrition Examination Survey (NHANES), the National Heart, Lung and Blood Institutes (NHLBI) Biologic Specimen and Data Repository Information Coordinating Center (BioLINCC), and the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial.  Proposed research should seek to maximize the scientific value of these stored collections and to provide researchers with an opportunity to generate preliminary data for subsequent research proposals. While other publicly available repositories  would be considered, depending on analyses to be conducted, nationally representative analyses will receive priority.  These applications need to provide justification why the data set is unique, and the research questions cannot be answered from a publicly available, nationally representative, data set.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=332007

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Department of Health and Human Services – National Institutes of Health –
BRAIN Initiative: Integration and Analysis of BRAIN Initiative Data (R01 Clinical Trial Not Allowed)

Letter of Intent Due Date: 30 days prior to application due date

Proposal Due Date: October 15, 2021

Expected Number of Awards:

Estimated Total Program Funding: $4,000,000

Award Ceiling:

Award Floor:

Funding Opportunity Number:  RFA-MH-21-135

Purpose: This is a reissue of RFA-MH-19-147. This FOA supports the development of software to visualize and analyze the data as part of programs of building the informatics infrastructure for the BRAIN Initiative. Other informatics programs include developing data standards that are needed to describe the new experiments that are being created by or used in the BRAIN Initiative (RFA-MH-19-146 ), and creating the data infrastructures that will house the data from multiple experimental groups ( RFA-MH-19-145 ). Each of the programs is aimed at building an infrastructure that is used by a particular sub-domain of experimentalists rather than building a single all-encompassing informatics infrastructure now. Building the infrastructure one experimental area at a time will ensure that the infrastructure is immediately useful to components of the research community. As our understanding of the brain improves, it may be possible to create linkages between these various sub-domain specific informatics programs. Investigators of the informatics programs should keep that goal in mind and build for the future even though the current efforts are more limited in scope.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=332030

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Department of Health and Human Services – National Institute of Health – Modular R01s in cancer control and population sciences (R01 clinical trial optional)

Proposal Due Date: November 8, 2021

Expected Number of Awards:

Estimated Total Program Funding:

Award Ceiling: $250,000

Award Floor:

Funding Opportunity Number: PAR-21-190

Purpose: This funding opportunity announcement (FOA) encourages applications for research in cancer control and population sciences. The overarching goal is to provide support to promote research efforts on novel scientific ideas that have the potential to substantially advance cancer research in statistical and analytic methods, epidemiology, cancer survivorship, cancer-related behaviors and behavioral interventions, health care delivery, and implementation science.

https://www.grants.gov/web/grants/view-opportunity.html?oppId=332086