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DHHS Funding Opportunities

FUNDING OPPORTUNITIES from the Department of Health and Human Services (DHHS)

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Department of Health and Human Services – Agency for Health Care Research and Quality – Large Research Projects for Prevention of Healthcare-Associated Infections (R01)

Proposal Due Date:                                                          May 26, 2025         

Expected Number of Awards:                                       

Estimated Total Program Funding:                             

Award Ceiling:                                                                    $500,000

Award Floor:                                                                      

Funding Opportunity Number:                                      PA-21-265

 

Purpose: This FOA issued by AHRQ invites grant applications for funding to conduct Large Research Projects (R01) that propose to advance the base of knowledge for detection, prevention, and reduction of Healthcare-Associated Infections (HAIs). This FOA describes the broad areas of HAI research for which funds are available to support Large Research Projects.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334065

 

Department of Health and Human Services – Centers for Disease Control – Strengthening Public Health Systems and Services through National Partnerships to Improve and Protect the Nation’s health

Proposal Due Date:                                                           August 9, 2021

Expected Number of Awards:                                        12

Estimated Total Program Funding:                              $2,000,000

Award Ceiling:                                                                    $0

Award Floor:                                                                       $0

Funding Opportunity Number:                                      CDC-RFA-OT18-18020403SUPP21

 

Purpose: This supplemental funding is only available to the organizations awarded under Funding Strategy 1 of CDC-RFA-OT18-1802: Strengthening Public Health Systems and Services through National Partnerships to Improve and Protect the Nation’s Health. Recipients are eligible to submit applications for FY21 CIO Project Plans according to the Target Population Category and Target Population Description for which they received initial funding in FY18. CDC expects to award projects in late September 2021. CDC is requesting applicants submit proposals for an 11-month budget period.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334146

 

Department of Health and Human Services – Health Resources and Services Administration – Service Area Competition

Proposal Due Date:                                                           September 7, 2021

Expected Number of Awards:                                        58

Estimated Total Program Funding:                            $252,557,000

Award Ceiling:                                                                    $0

Award Floor:                                                                       $0

Funding Opportunity Number:                                      HRSA-22-005

 

Purpose: This notice announces the opportunity to apply for funding under the Health Center Program’s Service Area Competition (SAC). The Health Center Program supports domestic public or private, nonprofit community-based and patient-directed organizations that provide primary health care services to the Nation’s medically underserved populations. The purpose of the SAC notice of funding opportunity (NOFO) is to ensure continued access to comprehensive, culturally competent, high-quality primary health care services for communities and populations currently served by the Health Center Program.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334313

 

Department of Health and Human Services – National Institutes of Health – Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)

Proposal Due Date:                                                           September 5, 2021

Expected Number of Awards:                                       

Estimated Total Program Funding:                             

Award Ceiling:                                                                   

Award Floor:                                                                      

Funding Opportunity Number:                                      PA-21-259

 

Purpose: This Funding Opportunity Announcement (FOA), issued by the National Institutes of Health (NIH), the Centers for Disease Control and Prevention (CDC), and the Food and Drug Administration (FDA), invites eligible United States small businesses to submit Small Business Innovation Research (SBIR) grant applications. United States small businesses that have the research capabilities and technological expertise to contribute to the R and D mission(s) of the NIH, CDC, and FDA awarding components identified in this FOA are encouraged to submit SBIR grant applications in response to identified topics (see PHS 2021-2 SBIR/STTR Program Descriptions and Research Topics for NIH, CDC, and FDA. This Parent Funding Opportunity Announcement does not accept clinical trials.


https://www.grants.gov/web/grants/view-opportunity.html?oppId=334628

 

Department of Health and Human Services – National Institutes of Health – Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required)

Proposal Due Date:                                                           September 5, 2021           

Expected Number of Awards:                                       

Estimated Total Program Funding:                             

Award Ceiling:                                                                   

Award Floor:                                                                      

Funding Opportunity Number:                                      PA-21-260   

 

Purpose:  This Funding Opportunity Announcement (FOA), issued by the National Institutes of Health (NIH) and the Centers for Disease Control and Prevention (CDC) invites eligible United States small businesses to submit Small Business Innovation Research (SBIR) grant applications. United States small businesses that have the research capabilities and technological expertise to contribute to the R and D mission(s) of the NIH and CDC awarding components identified in this FOA are encouraged to submit SBIR grant applications in response to identified topics (see PHS 2021-2 SBIR/STTR Program Descriptions and Research Topics for NIH, CDC, and FDA). This Parent Funding Opportunity Announcement requires that at least 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334631

 

Department of Health and Human Services – National Institutes of Health – Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)

Proposal Due Date:                                                           September 5, 2021

Expected Number of Awards:                                       

Estimated Total Program Funding:                             

Award Ceiling:                                                                   

Award Floor:                                                                      

Funding Opportunity Number:                                      PA-21-262

 

Purpose: This Funding Opportunity Announcement (FOA), issued by the National Institutes of Health (NIH) invites eligible United States small businesses to submit Small Business Technology Transfer (STTR) grant applications. United States small businesses that have the research capabilities and technological expertise to contribute to the R and D mission(s) of the NIH awarding components identified in this FOA are encouraged to submit STTR grant applications in response to identified topics (see PHS 2021-2 SBIR/STTR Program Descriptions and Research Topics for NIH, CDC, and FDA). This Parent Funding Opportunity Announcement does not accept clinical trials.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334629

 

Department of Health and Human Services – National Institutes of Health – Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Required)

Proposal Due Date:                                                           September 5, 2021

Expected Number of Awards:                                       

Estimated Total Program Funding:                             

Award Ceiling:                                                                   

Award Floor:                                                                      

Funding Opportunity Number:                                      PA-21-261

 

Purpose: This Funding Opportunity Announcement (FOA), issued by the National Institutes of Health (NIH) invites eligible United States small businesses to submit Small Business Technology Transfer (STTR) grant applications. United States small businesses that have the research capabilities and technological expertise to contribute to the R and D mission(s) of the NIH awarding components identified in this FOA are encouraged to submit STTR grant applications in response to identified topics (see PHS 2021-2 SBIR/STTR Program Descriptions and Research Topics for NIH, CDC, and FDA). This Parent Funding Opportunity Announcement requires that at least 1 clinical trial be proposed. The proposed project must be related to the programmatic interests of one or more of the participating NIH Institutes and Centers (ICs) based on their scientific missions

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334630

 

Department of Health and Human Services – National Institutes of Health – Network of the National Library of Medicine All of Us Program Center (U24) (Clinical Trial Optional)

Letter of Intent Due Date:                                              August 17, 2021

Proposal Due Date:                                                           September 17, 2021

Expected Number of Awards:                                        1         

Estimated Total Program Funding:                              $4,470,000 

Award Ceiling:                                                                    $3,200,000 

Award Floor:                                                                      

Funding Opportunity Number:                                      RFA-LM-21-002

 

Purpose: This Funding Opportunity Announcement (FOA) invites cooperative agreement (U24) applications for the Network of the National Library of Medicine (NNLM) All of Us Program Center (NACP). The mission of the NNLM is to provide U.S. health professionals, researchers, public health workforce, educators, and the public with equal access to biomedical and health information resources and data. NNLMs main goals are to work through libraries and other members to support a highly-trained workforce for biomedical and health information resources and data, improve health literacy, and increase health equity through information. The NNLM All of Us National Program Center (NAPC) will serve as the coordinating center and be responsible for the engagement, programs, partnerships, activities, and training offered by NNLM in support of the NIH All of Us Research Program. All of Us is working to improve health care through research by building a diverse database that can inform thousands of studies on a variety of health conditions. The NACP will continue to improve and innovate in two main functional areas: Training and Education, and Community Engagement. These two functional areas collaborate, coordinate, and cooperate to design, deliver, report, and evaluate innovative, responsive, and effective programs and services. They also work together to increase awareness about the NIH All of Us Research Program and to improve the health, digital, and related literacy skills that allow the general public to participate in long-term clinical research programs.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334677

 

Department of Health and Human Services – National Institutes of Health – Network of the National Library of Medicine All of Us Program Center (U24) (Clinical Trial Optional)

Letter of Intent Due Date:                                              30 days prior to application due date

Proposal Due Date:                                                           September 24, 2021

Expected Number of Awards:                                                   

Estimated Total Program Funding:                              $70,500,000

Award Ceiling:                                                                               

Award Floor:                                                                      

Funding Opportunity Number:                                      RFA-RM-21-025

 

Purpose: The purpose of the FIRST Cohort is to transform culture at NIH-funded extramural institutions by building a self-reinforcing community of scientists committed to diversity and inclusive excellence (defined below). Implementing and sustaining cultures of inclusive excellence within the program has the potential to be transformational for biomedical research at the awardee institutions and beyond. This community will be built through recruitment of faculty who are competitive for an advertised research tenure-track or equivalent faculty position (positions must be at the Assistant Professor (or equivalent) level), have not held a position at this level, and have demonstrated strong commitment to promoting diversity and inclusive excellence.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334690

 

Department of Health and Human Services – National Institutes of Health – Technology Development for Single-Molecule Protein Sequencing (R21 Clinical Trial not allowed)

Letter of Intent Due Date:                                              30 days prior to application due date

Proposal Due Date:                                                           October 1, 2021

Expected Number of Awards:                                       

Estimated Total Program Funding:                             

Award Ceiling:                                                                   

Award Floor:                                                                      

Funding Opportunity Number:                                      RFA-HG-21-002     

 

Purpose: This Funding Opportunity Announcement (FOA) solicits grant applications to catalyze major advances in single-molecule protein sequencing through technology development. The goal of this initiative is to achieve technological advances over the next five years that enable generation of protein sequencing data at sufficient scale, speed, cost and accuracy to use routinely in studies of genome biology and function, and in biomedical and clinical research in general.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334640

 

Department of Health and Human Services – National Institutes of Health – Technology Development for Single-Molecule Protein Sequencing (R01 Clinical Trial not allowed)

Letter of Intent Due Date:                                              30 days prior to application due date

Proposal Due Date:                                                           October 1, 2021

Expected Number of Awards:                                       

Estimated Total Program Funding:                             

Award Ceiling:                                                                   

Award Floor:                                                                      

Funding Opportunity Number:                                      RFA-HG-21-001     

 

Purpose: This Funding Opportunity Announcement (FOA) solicits grant applications to catalyze major advances in single-molecule protein sequencing through technology development. The goal of this initiative is to achieve technological advances over the next five years that enable generation of protein sequencing data at sufficient scale, speed, cost and accuracy to use routinely in studies of genome biology and function, and in biomedical and clinical research in general.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334639

 

Department of Health and Human Services – National Institutes of Health – Pediatric Immune System Ontogeny and Development (INTEND) (R01 Clinical Trial Not Allowed)

Proposal Due Date:                                                           October 5, 2021

Expected Number of Awards:                                       

Estimated Total Program Funding:                             

Award Ceiling:                                                                   

Award Floor:                                                                      

Funding Opportunity Number:                                      PAR-21-248

 

Purpose: The purpose of this Funding Opportunity Announcement (FOA) is to correlate immune system development patterns between two or more age groups- neonates, infants, and children and adolescents and further understand the impact of infectious diseases, microbiome and environmental factors on ontogeny and development of pediatric immune system, from birth, transitioning into adolescence and adulthood with focus impact during pregnancy and post-natal period.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334658

 

Department of Health and Human Services – National Institutes of Health – Cancer Target Discovery and Development (CTD2) (U01 Clinical Trial Not Allowed)

Letter of Intent Due Date:                                              30 days prior to application due date

Proposal Due Date:                                                           October 6, 2021

Expected Number of Awards:                                        12      

Estimated Total Program Funding:                             

Award Ceiling:                                                                   

Award Floor:                                                                      

Funding Opportunity Number:                                      PAR-21-274

 

Purpose: Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) will support the program “Cancer Target Discovery and Development (CTD2, pronounced cee-tee-dee-squared).  CTD2 is focused on efforts that advance cancer research by bridging the knowledge gap between the large volumes of comprehensive molecular characterizations of many cancer types and studies of the underlying etiology of cancer development, progression, and/or metastasis.  The primary purpose of CTD2 is to advance the following areas:  Improving the understanding of how mutations in cancer-associated genes affect the protein activity (e.g., gain-of-function, loss-of-function, or neomorphic function) within the cellular pathway(s) they are part of and the cellular changes that result within the context of various tumors and the microenvironment;  Identifying new molecular targets with the goal to understand their wiring mechanisms and how overcome innate and/or acquired resistance to therapies, particularly clinical resistance related to inter- and intra- tumor heterogeneity; and Developing efficient strategies to identify appropriate multiple targets and optimal combination of perturbagens (chemical or biological; immunotherapeutics being a prime example of the latter) with the potential to eliminate all cancer cells, despite their clonal heterogeneity and their surrounding microenvironment.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334676

 

Department of Health and Human Services – National Institutes of Health – Metabolic Dysregulation and Cancer Risk Program, Research Grants: a Transdisciplinary Approach to Obesity-Associated Research (U01 Clinical Trial Optional)

Letter of Intent Due Date:                                              September 20, 2021

Proposal Due Date:                                                           October 6, 2021

Expected Number of Awards:                                       

Estimated Total Program Funding:                             

Award Ceiling:                                                                   

Award Floor:                                                                      

Funding Opportunity Number:                                      RFA-CA-21-021

 

Purpose: The National Cancer Institute (NCI) invites research grant proposals for transdisciplinary studies that will enhance our knowledge of the dynamics and underlying mechanisms that link obesity, metabolic dysregulation and increased cancer risk. Through this Funding Opportunity Announcement (FOA), the Metabolic Dysregulation and Cancer Risk Program will focus on metabolic dysregulation as the key process linking obesity with cancer risk.  For the purpose of this FOA, metabolic dysregulation is defined as alterations in glucose utilization and storage, insulin sensitivity, and/or lipid metabolism. Proposals should specifically seek to advance our understanding of how metabolic dysregulation in individuals affects cancer risk and identify mechanisms that will enhance (i) cancer risk prediction, (ii) screening for high-risk individuals in clinical settings, and (iii) identification of potential targets for preventive and therapeutic interventions. This FOA is published in parallel with RFA-CA-21-022 Coordinating Center for the Metabolic Dysregulation and Cancer Risk Program: a Transdisciplinary Approach to Obesity-associated Research (U24 Clinical Trial Not Allowed). The individual research grants and the Coordinating Center funded under these FOAs together will constitute the Metabolic Dysregulation and Cancer Risk Program.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334577

 

Department of Health and Human Services – National Institutes of Health – Coordinating Center for the Metabolic Dysregulation and Cancer Risk Program: A Transdisciplinary Approach to Obesity-Associated Cancer Research (U24 Clinical Trial Not Allowed)

Letter of Intent Due Date:                                              September 20, 2021

Proposal Due Date:                                                           October 6, 2021

Expected Number of Awards:                                       

Estimated Total Program Funding:                             

Award Ceiling:                                                                    $550,000     

Award Floor:                                                                      

Funding Opportunity Number:                                      RFA-CA-21-022

 

Purpose: The Metabolic Dysregulation and Cancer Risk Program is focused on metabolic dysregulation as the key process linking obesity with cancer risk. Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) will support a Coordinating Center to facilitate coordination across multiple individual research project grants. The overarching goal of the Metabolic Dysregulation and Cancer Risk Program is to enhance our knowledge of the dynamics, and underlying mechanisms, that link obesity, metabolic dysregulation, and increased cancer risk.   The Coordinating Center will have several responsibilities, including, but not limited to, provide administrative support to the Metabolic Dysregulation and Cancer Risk Program, facilitate and participating in collaborative research, create standard operating procedures and best practices to identify common measures/targets, collect core common data elements and biological samples (when appropriate), facilitate communication across researchers, provide meeting support, coordinating reviews of applications and distribution of research funds, create and maintain the Program website, and facilitate deposition of data to NIH repositories (when appropriate). This FOA is published in parallel with RFA-CA-21-021 Research Project Grants for the Metabolic Dysregulation and Cancer Risk Program: a Transdisciplinary Approach to Obesity-associated Research (U01 Clinical Trial Optional). The Coordinating Center and the individual research grants funded under these FOAs together will constitute the Metabolic Dysregulation and Cancer Risk Program.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334578

 

Department of Health and Human Services – National Institutes of Health – Identification and Characterization of Bioactive Microbial Metabolites for Advancing Research on Microbe-Diet-Host Interactions (R01 Clinical Trial Not Allowed)

Letter of Intent Due Date:                                              September 20, 2021

Proposal Due Date:                                                           October 20, 2021

Expected Number of Awards:                                       

Estimated Total Program Funding:                             

Award Ceiling:                                                                   

Award Floor:                                                                      

Funding Opportunity Number:                                      PAR-21-253

 

Purpose: The purpose of the Funding Opportunity Announcement is to invite applications to identify and characterizemicrobial metabolites that will establish causal associations between microbial metabolism and host health and disease. Data acquired through this initiative will be used to create aknowledgebase of microbial metabolites and associated functions that will be provided to the research community. Development of the database and knowledge portal for these awards will be supported under a separate initiative: RFA-DK-21-014, namely Identification and Characterization of Bioactive Microbial Metabolites for Advancing Research on Microbe-Diet-Host Interactions Knowledgebase Management Center U24 Resource-Related Research Projects  Cooperative Agreements.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334591

 

Department of Health and Human Services – National Institutes of Health – Identification and Characterization of Bioactive Microbial Metabolites for Advancing Research on Microbe-Diet-Host Interactions Knowledgebase Management Center (U24 Clinical Trial Not Allowed)

Letter of Intent Due Date:                                              September 20, 2021

Proposal Due Date:                                                           October 20, 2021

Expected Number of Awards:                                       

Estimated Total Program Funding:                             

Award Ceiling:                                                                   

Award Floor:                                                                      

Funding Opportunity Number:                                      RFA-DK-21-014

 

Purpose: This Funding Opportunity Announcement (FOA) invites U24 cooperative agreement applications for a Knowledge Management Center (KMC) to support grantees engaged in identifying and characterizing microbial metabolites for building a knowledgebase. A companion FOA [PAR-21-253, Identification and Characterization of Bioactive Microbial Metabolites for Advancing Research on Microbe-Diet-Host Interactions (R01 Clinical Trial Not Allowed)] invites applications for identifying and characterizing microbial metabolites that will be used by this KMC to create a knowledgebase on microbial metabolites that is accessible to the research community.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334580

 

Department of Health and Human Services – National Institutes of Health – Emergency Awards: Antiviral Drug Discovery (AViDD) Centers for Pathogens of Pandemic Concern (U19 Clinical Trial Not Allowed)

Letter of Intent Due Date:                                              30 days prior to application due date

Proposal Due Date:                                                           October 22, 2021

Expected Number of Awards:                                       

Estimated Total Program Funding:                             

Award Ceiling:                                                                   

Award Floor:                                                                      

Funding Opportunity Number:                                      RFA-AI-21-050

 

Purpose: This Funding Opportunity Announcement (FOA) solicits applications from single institutions or consortia of institutions to participate in the Antiviral Drug Discovery (AViDD) Centers for Pathogens of Pandemic Concern program. The purpose of this program is to support comprehensive multidisciplinary research Centers focused on innovative antiviral drug development targeting coronaviruses (CoVs), emphasizing SARS-CoV-2, and one or more select RNA viruses with pandemic potential. NIAID is issuing this FOA in response to the declared public health emergency issued by the Secretary, HHS, for the 2019 Novel Coronavirus (COVID-19), and within the provisions described in the “American Rescue Plan Act of 2021.”

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334659

 

Department of Health and Human Services – National Institutes of Health – Transformative Artificial Intelligence and Machine Learning Based Strategies to Identify Determinants of Exceptional Health and Life Span (R21/R33 Clinical Trial Not Allowed)

Letter of Intent Due Date:                                              September 28, 2021

Proposal Due Date:                                                           October 28, 2021              

Expected Number of Awards:                                       

Estimated Total Program Funding:                 

Award Ceiling:                                                                   

Award Floor:                                                                      

Funding Opportunity Number:                                      RFA-AG-22-022

Purpose: This Funding Opportunity Announcement (FOA) will use the NIH Phased Innovation Award mechanism (R21/R33) to develop novel transformative artificial intelligence/machine learning (AI/ML) strategies and computer automation to integrate, extract, and interpret multi-omic (i.e., genome, epigenome, transcriptome, proteome, metabolome, microbiome, phenome) data sets from human exceptional longevity (EL) cohorts and multiple non-human species that display wide variation in life span and decipher the relationships between DNA, RNA, proteins, metabolites, and other cell variables, as well as links to disease risks and exceptionally healthy aging. The investigative team(s) for this FOA is/are expected to be multi-disciplinary, encompassing expertise in AI/ML, aging biology, comparative biology, and bio/chemo informatics. Investigative teams will design/develop intelligent and innovative algorithms and novel AI/ML based computational strategies during the R21 phase, then apply the developed AI/ML tools to complex, heterogenous multi-omic data sets from exceptional healthy aging human cohorts and non-human species in the R33 phase to discover novel protective molecular factors, biological process(es) and interlayer regulatory mechanism(s) that govern the exceptional aging process and develop translational strategies on omic-based therapeutic target(s) to prevent or delay age-related diseases including Alzheimer’s disease and Alzheimer’s disease-related dementias (AD/ADRD) and enhance the human health span. This FOA strongly encourages collaboration (including public-private partnerships), coordination, data and resource exchange among researchers studying exceptional longevity and with related NIH-supported omics activities being pursued in different cohorts such as the Trans-Omics for Precision Medicine (TOPMED), the Accelerating Medicines Partnership-Alzheimer’s Disease (AMP-AD), and the Alzheimer’s Disease Sequencing Project (ADSP). Prospective applicants are strongly encouraged to contact NIA staff to discuss their proposed projects to ensure their responsiveness to this FOA. Applications using only the R21 mechanism or the R33 mechanism will not be accepted under this FOA.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334571

 

Department of Health and Human Services – National Institutes of Health – Grants for Early Medical/Surgical Specialists’ Transition to Aging Research (GEMSSTAR) (R03 Clinical Trial Optional)

Letter of Intent Due Date:                                              October 2, 2021

Proposal Due Date:                                                           November 2, 2021            

Expected Number of Awards:                                       

Estimated Total Program Funding:                 

Award Ceiling:                                                                   

Award Floor:                                                                      

Funding Opportunity Number:                                      RFA-AG-22-027

Purpose: The goal of the GEMSSTAR program is to provide support for early-career physician-scientists trained in medical or surgical specialties or early-career dentist-scientists to launch careers as future leaders in aging- or geriatric-focused research. To achieve this goal, the GEMSSTAR Funding Opportunity Announcement (FOA) provides small grants to conduct transdisciplinary aging research that will yield pilot data and experience for subsequent aging research projects.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334573

 

Department of Health and Human Services – National Institutes of Health – NIMH Career Transition Award for Tenure-Track Intramural Investigators (K22 No Independent Clinical Trials)

 Proposal Due Date:                                                         November 12, 2021           

Expected Number of Awards:                                       

Estimated Total Program Funding:                             

Award Ceiling:                                                                   

Award Floor:                                                                      

Funding Opportunity Number:                                      PAR-21-239

 

Purpose: Reissue of PAR-18-755. The primary goal of the NIMH Career Transition Award for Tenure-Track Intramural Investigators (K22) Program (hereafter abbreviated as the NIMH Career Transition K22 Program) is to provide support for career intramural investigators at NIMH who aim to transition from the Division of Intramural Research Programs (DIRP) to an independent research faculty position in the extramural community. Applicants should have a demonstrated record of meritorious research in mental health-related fields


https://www.grants.gov/web/grants/view-opportunity.html?oppId=334648

 

Department of Health and Human Services – National Institutes of Health – Growing Great Ideas: Research Education Course in Product Development and Entrepreneurship for Life Science Researchers (UE5 Clinical Trial Not Allowed)

Letter of Intent Due Date:                                              October 18, 2021

Proposal Due Date:                                                           November 18, 2021                       

Expected Number of Awards:                                       

Estimated Total Program Funding:                 

Award Ceiling:                                                                   

Award Floor:                                                                      

Funding Opportunity Number:                                      RFA-DA-22-020

Purpose: This FOA solicits applications to develop the customized curriculum and to implement the education programs/short courses in biomedical entrepreneurship, innovation and biomedical product development specifically targeting scientists working in the field of drug addiction research. The institution proposing the course must be an institution that has an established and well-recognized entrepreneurship teaching program with the demonstrated ability and passion to adapt/develop and deliver the integrated curriculum for the academic life scientists.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334579

 

Department of Health and Human Services – National Institute of Health – Innate Immune Memory Impacting HIV Acquisition and/or Control (R21 Clinical Trial Not Allowed)

Letter of Intent Due Date:                                              30 days prior to application due date

Proposal Due Date:                                                           December 6, 2021                                    

Expected Number of Awards:                                       

Estimated Total Program Funding:                             

Award Ceiling:                                                                   

Award Floor:                                                                      

Funding Opportunity Number:                                      RFA-AI-21-041

 

Purpose: The purpose of this Funding Opportunity Announcement is to investigate innate immune cell effector functions and innate immune memory as a means to prevent HIV infection and/or establishment of disease.  Exploratory research from basic molecular mechanisms, translational work, and clinical research examining innate memory are encouraged.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334613

 

Department of Health and Human Services – National Institutes of Health—Computationally-Defined Behaviors in Psychiatry (R21 Clinical Trial Optional)

Letter of Intent Due Date:                                              November 8, 2021

Proposal Due Date:                                                           December 8, 2021            

Expected Number of Awards:                                       

Estimated Total Program Funding:                 

Award Ceiling:                                                                   

Award Floor:                                                                      

Funding Opportunity Number:                                      PAR-21-264

Purpose: Reissue of RFA-MH-19-240. This Funding Opportunity Announcement (FOA) solicits proposals for research projects that will apply computational approaches to develop parametrically detailed behavioral assays across mental-health relevant domains of function. These projects should focus on behavior in humans and test computational models in healthy subjects. For future applications, NIMH is particularly interested in behavioral measures, models, and parameters that have the potential for back-translation from humans to animals, especially for pre-clinical therapeutics development. NIMH is also interested in models that can be extended to clinical populations in the future.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334598

 

Department of Health and Human Services – National Institutes of Health— Computational Approaches for Validating Dimensional Constructs of Relevance to Psychopathology (R01 Clinical Trial Optional)

Letter of Intent Due Date:                                              November 8, 2021

Proposal Due Date:                                                           December 8, 2021            

Expected Number of Awards:                                       

Estimated Total Program Funding:                 

Award Ceiling:                                                                    $500,000

Award Floor:                                                                      

Funding Opportunity Number:                                      PAR-21-263

Purpose: Reissue of RFA-MH-19-242.This Funding Opportunity Announcement (FOA) solicits proposals for research projects that will use computational approaches to test the validity of dimensional constructs in the NIMH Research Domain Criteria matrix (or similar constructs based on comparable criteria). Some elements of the RDoC matrix have been updated since its first release, but a thorough data-driven validation that broadly explores, compares, and validates the constructs within the matrix has not been performed. This FOA seeks research that addresses the following questions: do the different domains of behavior segregate from each other? How much do they rely on distinct vs. overlapping neural circuits? What are the relationships between domains, constructs and subordinate subconstructs, both in terms of their correlational structure and their underlying neural circuitry? By answering these questions, proposals will test integrative models of functioning and identify dysregulation in psychopathology-related mechanisms that may cut across traditional diagnostic categories and may change over time. This FOA seeks to promote projects where the computational and the experimental components are well-integrated. The ultimate goal is to advance translational research that will identify novel classification approaches and/or treatment targets, and lead to more effective and timely interventions for serious mental illness.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334599

  

Department of Health and Human Services – National Institutes of Health – Dyadic Interpersonal Processes and Biopsychosocial Outcomes (R01 Clinical Trials Not Allowed)

Proposal Due Date:                                                           February 5, 2022

Expected Number of Awards:                                       

Estimated Total Program Funding:                             

Award Ceiling:                                                                   

Award Floor:                                                                      

Funding Opportunity Number:                                      PAR-21-281

 

Purpose: This funding opportunity announcement (FOA) invites basic and/or methodological research projects that seek to illuminate or measure independent and interdependent health-related effects within dyads. For the purpose of this FOA, a dyad is a unit of two individuals whose interactions and influences on one another are nested within larger social contexts and networks. Both animal and human subjects research projects are welcome. Types of projects submitted under this FOA include but are not limited to, studies observational studies involving humans, or existing/synthesized datasets studies. Applications proposing studies that prospectively assign human participants to conditions meet the NIH definition of basic research and fall within the NIH definition of clinical trials (see, e.g., NOT-OD-19-024). Researchers proposing basic science experimental studies involving human participants (i.e., experimentally manipulate independent variables) should consider the companion FOA PAR-XX-XXX “Dyadic Interpersonal Processes and Biopsychosocial outcomes (R01 Basic Experimental Studies with Humans).

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334641

 

Department of Health and Human Services – National Institutes of Health – Dyadic Interpersonal Processes and Biopsychosocial Outcomes (R01 – Basic Experimental Studies with Humans)

Proposal Due Date:                                                           March 5, 2022

Expected Number of Awards:                                       

Estimated Total Program Funding:                             

Award Ceiling:                                                                   

Award Floor:                                                                      

Funding Opportunity Number:                                      PAR-21-280

 

Purpose: This funding opportunity announcement (FOA) invites basic and/or methodological research projects that seek to illuminate or measure independent and interdependent health-related effects within dyads. For the purpose of this FOA, a dyad is a unit of two individuals whose interactions and influences on one another are nested within larger social contexts and networks. Types of projects submitted under this FOA include studies that prospectively assign human participants to conditions (i.e., experimentally manipulate independent variables) and that assess biomedical and/or behavioral outcomes in humans to understand fundamental aspects that emanate from intra-dyadic phenomena. NIH considers such studies as prospective basic science studies involving human participants that meet the NIH definition of basic research and fall within the NIH definition of clinical trials (see, e.g., NOT-OD-19-024). Applications proposing studies using model animal research, observational studies involving humans, or existing/synthesized datasets should submit under the companion FOA PAR-XX-XXX ” Dyadic interpersonal processes and biopsychosocial outcomes (R01 Clinical Trials Not Allowed).

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334657

 

Department of Health and Human Services – National Institutes of Health – Exploiting in Vivo or in Situ Imaging Approaches to Understand HIV-relevant Processes In The Context of Substance Use Disorders (R61/R33 Clinical Trials Optional)

Letter of Intent Due Date:                                              July 11, 2022

Proposal Due Date:                                                           August 11, 2022

Expected Number of Awards:                                       

Estimated Total Program Funding:                             

Award Ceiling:                                                                   

Award Floor:                                                                      

Funding Opportunity Number:                                      RFA-DA-23-001

 

Purpose: The purpose of this initiative is to support projects that further develop or exploit advances using in situ or in vivo imaging or related technologies to investigate HIV/SIV infection, latent reservoirs, the pathogenic consequences of HIV/SIV infection, or the effects of HIV/SIV or substance use disorder (SUD) therapies.  Applicants may propose primate or human studies to investigate blood, lymphoid, or brain tissues.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334642

 

Department of Health and Human Services – Office of the Assistant Secretary for Health – State, Local, Territorial, and Tribal (SLTT) Partnership Programs to Reduce Maternal Deaths due to Violence

Proposal Due Date:                                                           August 12, 2021                                        

Expected Number of Awards:                                        15

Estimated Total Program Funding:                              $4,300,000

Award Ceiling:                                                                    $300,000     

Award Floor:                                                                      

Funding Opportunity Number:                                      WH-AST-21-002

 

Purpose: The Office on Women’s Health announces the availability of funds for Fiscal Year (FY) 2021 cooperative agreements under the authority of section 1703(a) of the PHS Act (42 U.S.C. § 300u-2(a)), and section 229 of the PHS Act (42 U.S.C. § 237a). 

This notice solicits applications for state, local, territorial, and tribal (SLTT) partnership projects designed to identify and reduce deaths among pregnant and postpartum women due to violence. For the purposes of this Notice of Funding Opportunity (NOFO), violent maternal deaths are defined as maternal deaths due to homicide and suicide.  Applicants receiving funding will be expected to: (1) Establish or expand programs that review, identify, and track maternal deaths due to violence; (2) Implement evidence-based interventions to improve outcomes and reduce deaths among pregnant and postpartum women due to violence; (3)  Develop a sustainability plan for maintaining the program when the cooperative agreement award ends.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=332917

 

Department of Health and Human Services – Office of the Assistant Secretary for Health – State, Local, Territorial, and Tribal (SLTT) Partnership Programs to Reduce Maternal Deaths due to Violence

Proposal Due Date:                                                           August 12, 2021                                        

Expected Number of Awards:                                       

Estimated Total Program Funding:                              $4,300,000

Award Ceiling:                                                                    $300,000     

Award Floor:                                                          

Funding Opportunity Number:                                      WH-AST-21-003

 

Purpose: The Office on Women’s Health announces the availability of funds for Fiscal Year (FY) 2021 cooperative agreements under the authority of section 1703(a) of the PHS Act (42 U.S.C. § 300u-2(a)), and section 229 of the PHS Act (42 U.S.C. § 237a). This notice solicits applications for state, local, territorial, and tribal (SLTT) partnership projects designed to identify and reduce deaths among pregnant and postpartum women due to violence. For the purposes of this Notice of Funding Opportunity (NOFO), violent maternal deaths are defined as maternal deaths due to homicide and suicide. Applicants receiving funding will be expected to: (1) Establish or expand programs that review, identify, and track maternal deaths due to violence; (2) Implement evidence-based interventions to improve outcomes and reduce deaths among pregnant and postpartum women due to violence; (3) Develop a sustainability plan for maintaining the program when the cooperative agreement award ends.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=332893

 

Department of Health and Human Services – Office of the Assistant Secretary for Health – Promoting Vaccine Confidence in Local Communities through Partnership with Regional Health Offices

Proposal Due Date:                                                           August 17, 2021                                        

Expected Number of Awards:                                        8         

Estimated Total Program Funding:                              $750,000

Award Ceiling:                                                                    $125,000     

Award Floor:                                                                      

Funding Opportunity Number:                                      NV-VSR-21-001

 

Purpose: The Office of the Assistant Secretary for Health, Office of Infectious Disease and HIV/AIDS Policy (OIDP) announces the availability of funds for Fiscal Year (FY) 2021 under the authority of sections 1702 and 1703 of the Public Health Service Act, (42 U.S.C. 300u-1 and 300u-2).

 OIDP oversees the National Vaccine Program that provides strategic leadership and coordination of vaccine and immunization activities among federal agencies and other stakeholders with the goal to help reduce the burden of preventable infectious disease. OIDP has maintained that vaccine confidence is critical to improving vaccination coverage rates and has prioritized its work on strengthening public trust in vaccines. This project aligns with the priority of the OASH to respond to and prevent the coronavirus disease (COVID-19) and other vaccine-preventable diseases, and strategic goals of the HHS including “Goal 2: Protect the health of Americans Where they Live, Learn, Work, and Play” and “Goal 3: Strengthen the Economic and Social Well-being of Americans Across the Lifespan”.

Vaccines are among the most effective public health interventions to promote health and prevent diseases. According to the World Health Organization, vaccines prevent between two and three million deaths per year globally. An essential pillar of success for a national vaccine program is maintaining high rates of immunity in communities. To reach the necessary number of vaccinated individuals to achieve community immunity, a high level of public trust in the immunization systems, i.e., vaccine confidence, is needed. In the United States, vaccination coverage for adolescents and adults have generally remained persistently low. Even among children, where coverage rates are high at 90% or higher for most vaccines, nearly 12% of parents refuse at least one recommended vaccine for their children and approximately 30% delay one or more vaccines from being administered to their children. Additionally, non-medical exemptions from school immunization requirements have hindered higher vaccination coverage in children. These data suggest a deficiency in public trust in vaccines. If the national trend of reduced vaccine confidence continues, gains made over the past decades in preventing serious and potentially deadly diseases are threatened. Such erosion may result in more frequent and larger outbreaks of preventable diseases that strain the healthcare system and public health infrastructure and pose an increased threat to national security.

Vaccine confidence is defined as having confidence in 1) the safety and efficacy of a vaccine (confidence in the product), 2) the competence of the healthcare professional administering the vaccine (confidence in the provider), and 3) trusting the motivations of the policymakers deciding which vaccines are recommended and when (confidence in the policy). Given the direct relationship between vaccine confidence and vaccine decision making, there is a critical need to understand the determinants of and steps that can be taken to improve vaccine confidence. Efforts to better understand vaccine confidence so that effective interventions can be implemented are ongoing. For example, the National Vaccine Advisory Committee (NVAC), a federal advisory committee of external experts that advises the Assistant Secretary for Health, HHS, is continuing its work to update the report on recommendations regarding determinants of vaccination confidence (Assessing the State of Vaccine Confidence in the United States: Recommendations from the National Vaccine Advisory Committee. Public Health Rep. 2015 Nov–Dec; 130(6):573–595). NVAC recommended strategies to improve the public’s confidence in vaccines and provided guidance on the use of effective vaccination policies to promote evidence-informed best practices. However, practical solutions to engage healthcare providers, academicians, immunization program managers, vaccine advocates, vaccine manufacturers, and other partners in local communities are needed.

This initiative seeks to expand traditional immunization partnerships to plan, implement, and evaluate evidence-based practices and develop novel approaches to increase confidence in vaccines in local communities, particularly partnerships with minority-serving or other advocacy organizations that work with populations with low vaccination rates (e.g., African Americans, Hispanics, and Native Americans; residents in rural communities, medical assistants [when compared to other medical professions]; some immigrant and refugee communities; and young adults [when compared to older adults] and teens and adolescents [when compared to younger children]).

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=332874

 

Department of Health and Human Services – Office of the Assistant Secretary for Health – Framework to Address Health Disparities through Collaborative Policy Efforts: Coordinating Center

Proposal Due Date:                                                           August 23, 2021                                        

Expected Number of Awards:                                        1         

Estimated Total Program Funding:                 

Award Ceiling:                                                                    $500,000     

Award Floor:                                                                       $0      

Funding Opportunity Number:                                      MP-CPI-21-003

 

Purpose: The Office of the Assistant Secretary for Health (OASH) and the Office of Minority Health (OMH) announce the availability of funds for Fiscal Year (FY) 2021 under the authority of 42 U.S.C. § 300u-6 (Section 1707 of the Public Health Service Act). OMH is dedicated to improving the health of racial and ethnic minority populations through the development of health policies and programs that will help eliminate health disparities. Through its demonstration projects, OMH supports the identification of effective approaches for improving health outcomes with the ultimate goal of promoting dissemination and sustainability of these approaches. This particular cooperative agreement aligns with the Office of the Assistant Secretary for Health priority on the elimination of health disparities and HHS Strategic Goal 2, Objective 2: Prevent, treat and control communicable diseases and chronic conditions.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=328672

 

Department of Health and Human Services – Office of the Assistant Secretary for Health- Framework to Address Health Disparities through Collaborative Policy Efforts: Demonstration Projects

Proposal Due Date:                                                           August 23, 2021                                        

Expected Number of Awards:                                        4         

Estimated Total Program Funding:                              $1,500,000

Award Ceiling:                                                                    $375,000     

Award Floor:                                                                                  

Funding Opportunity Number:                                      MP-CPI-21-004

 

Purpose: The Office of the Assistant Secretary for Health (OASH) and the Office of Minority Health (OMH) announce the availability of funds for Fiscal Year (FY) 2021 under the authority of 42 U.S.C. § 300u-6 (Section 1707 of the Public Health Service Act). OMH is dedicated to improving the health of racial and ethnic minority populations through the development of health policies and programs that will help eliminate health disparities. Through its demonstration grants, OMH supports the identification of effective approaches for improving health outcomes with the ultimate goal of promoting dissemination and sustainability of these approaches. These particular cooperative agreements align with the OASH priority on the elimination of health disparities and the following HHS Strategic Plan goals: (1) Strategic Goal 1: Reform, Strengthen, and Modernize the Nation’s Healthcare System; (2) Strategic Goal 2: Protect the Health of Americans Where They Live, Learn, Work, and Play; and (3) Strategic Goal 3: Strengthen the Economic and Social Well-Being of Americans.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=332939

 

Department of Health and Human Services – Substance Abuse and Mental Health Services Administration – Poverty Research Center

Proposal Due Date:                                                           August 9, 2021

Expected Number of Awards:                                        1

Estimated Total Program Funding:                              $2,615,000

Award Ceiling:                                                                    $2,615,000

Award Floor:                                                                       $0

Funding Opportunity Number:                                      AE-21-001

 

Purpose: Announcement of the availability of funds and request for applications for a cooperative agreement to establish a National Research Center on Poverty and Economic Mobility.

 

https://www.grants.gov/web/grants/view-opportunity.html?oppId=334623

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