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Member Research and Reports

Member Research and Reports

Effectiveness of Run-in Period in Randomized Controlled Trials Examined by UAB

Few past studies have assessed characteristics that inform the optimal design of obesity randomized controlled trials (RCTs), such as a pre-randomization run-in period (during which no treatment is administered). Dr. Olivia Affuso, associate professor in the department of epidemiology at the University of Alabama at Birmingham (UAB) School of Public Health – with colleagues Dr. Kathryn A. Kaiser, instructor in the department of biostatistics, Dr. Tiffany L. Carson, assistant professor in the division of preventive medicine, and Dr. David B. Allison, associate dean for science – recently examined 311 obesity RCTs published between January 2007, and July 2009, that investigated weight loss or weight gain prevention as a primary or secondary end-point. Variables included the run-in period, pre-post intervention weight loss, the study duration (time), the intervention type, the percentage of female participants, and the degree of obesity regarding each participant.