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Member Research and Reports

Member Research and Reports

Georgia Southern Examines Epithelial Ovarian Cancer Mortality among Hispanic Women

Over the past half century the proportion of Hispanics in the U.S. population has been steadily increasing, and groups of Hispanic origin have diversified. Despite notable racial and ethnic disparities in ovarian cancer (OC) mortality, population-based studies on OC among Hispanic females are lacking.

The disparities in OC 5 year survival and mortality were examined using log-rank tests and Cox proportional hazards models, adjusted for sociodemographic and pathological characteristics, time of diagnosis, receipt of resection surgery and county socioeconomic status. Trends in five-year survival rates were examined using joinpoint regression models.

The five-year survival was lowest in Puerto Ricans (median survival: 33 months; survival rate: 31.07 percent) and was highest in the “Other” Hispanic subgroup (median survival: 59 months; survival rate: 49.14 percent) (log-rank test: P < 0.001). The OC-specific death hazards in Mexicans (HRadj: 0.82, 95 percent CI: 0.67 – 1.00, P = 0.048), South or Central Americans (HRadj: 0.77, 95 percent CI: 0.62 – 0.96, P = 0.005) and Other Hispanics (HRadj: 0.76, 95 percent CI: 0.63 – 0.92, P = 0.038) were significantly lower than for Puerto Ricans.

Mortality rates of Cubans and Puerto Ricans were not significantly different. During 1992–2008, there were non-significant increasing trends in the five-year all-cause and OC-specific survival rates: from 43.37 to 48.94 percent (APC = 0.41, P = 0.40) and from 48.72 percent to 53.46 percent (APC = 0.29, P = 0.50), respectively.

OC mortality in Hispanic patients varied by sub-ethnicity. This heterogeneity should be considered in future cancer data collection, reports and research.

Epithelial ovarian cancer mortality among Hispanic women: Sub-ethnic disparities and survival trend across time: An analysis of SEER 1992–2013,” was recently published in Cancer Epidemiology.

Dr. Chen Chen, alumni, was the lead author, and Dr. Yelena Tarasenko, department of epidemiology at Georgia Southern University Jiann-Ping Hsu College of Public Health  was a senior author. The study would not be possible without significant contribution and expertise of Drs. Talar Markossian in health policy and administration and Dr. Abigail Silva a disparities and evaluation researcher, both at Loyola University. While working on her dissertation on a related topic, Dr. Chen completed SEER* Stat Basics and Advanced Training at APHA. Dr. Chen was also one of the first DrPH Leadership students who received CPH certification.