A collaborative study including Dr. Levi Ross, assistant professor of community health behavior and education at the Jiann-Ping Hsu College of Public Health Georgia Southern University discusses some practical considerations regarding Community-Based Participatory Research for addressing cancer health disparities. There is a consensus about the benefits of community-based participatory research and the important role it can play in reducing cancer health disparities. Although every community-based participatory research project is unique in many ways, several fundamental issues deserve consideration. We discuss issues concerning community representation, possible tensions within community-based participatory research (CBPR) projects, and staffing CBPR projects. Flexibility, open-mindedness, transparency, and above all, caring, are characteristics that best ensure successful and rewarding outcomes.