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Member Research & Reports

Member Research & Reports

Harvard: Botswana Study Shows 96% Rate of Viral Suppression for Patients on HIV Drugs

Botswana appears to have achieved very high rates of HIV diagnosis, treatment, and viral suppression — much better than most Western nations, including the United States — according to a new study from Harvard T.H. Chan School of Public Health and colleagues in Botswana. The findings suggest that even in countries with limited resources where a large percentage of the population is infected with HIV, strong treatment programs can help make significant headway against the HIV/AIDS epidemic. The study was published online March 23 in The Lancet HIV.

“By now, we hoped to have an HIV vaccine. That hasn’t happened. Ironically, treatment of HIV-infected persons may be our most effective, efficient way to prevent new infections. These results show that Botswana has made great progress in reducing the number of people who are infectious to others,” said Dr. Max Essex, Mary Woodard Lasker Professor of Health Sciences, chair of the Harvard T.H. Chan School of Public Health AIDS Initiative, and chair of the Botswana Harvard AIDS Institute Partnership.

Global HIV programs have continued to face challenges in achieving the high rates of testing and treatment needed to optimize health and reduce new infections. Mounting evidence suggests that providing antiretroviral treatment (ART) to all people living with HIV, regardless of the stage of their disease, can help. In 2014, the Joint United Nations Programme on HIV/AIDS (UNAIDS) proposed new testing and treatment targets: that 90 percent of all people living with HIV know their HIV status; that 90 percent diagnosed with HIV be given ART; and that 90 percent who receive treatment have virologic suppression — very low blood levels of HIV — by the year 2020.

The researchers looked at the achievability of the UNAIDS targets in Botswana — a middle-income African nation where 25 percent of the population aged 15-49 is HIV positive but which also has a mature public ART program — by directly measuring HIV status, treatment, and viral suppression among 12,610 people from 30 communities across the country between October 2013 and November 2015. Study participants were drawn from a large, ongoing HIV prevention study in Botswana. The participants responded to a questionnaire, had their blood tested for HIV if their status wasn’t known, and, if they were infected with HIV, their viral load was checked.

“This is significant work as it provides further evidence that the UNAIDS 90-90-90 treatment target is both realistic and achievable,” said UNAIDS Executive Director Michel Sidibé, who was not involved in the study.

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