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Member Research and Reports

Member Research and Reports

Harvard: Mumps Resurgence Likely Due to Waning Vaccine-derived Immunity

A resurgence of mumps in the U.S. among vaccinated young adults appears to be due to waning of vaccine-induced immunity, according to a new analysis from Harvard T.H. Chan School of Public Health.

Researchers found that vaccine-derived immune protection against mumps persists an average of about 27 years after the last dose. The findings suggest that, in addition to the currently recommended two doses of mumps vaccine in childhood, a third dose at age 18 or booster shots may help sustain protection among adults.

The study was published March 21, in Science Translational Medicine.

“This analysis helps address a persistent question surrounding the recent mumps outbreaks, pointing to the key role played by waning vaccine induced immunity, and helps frame the research and policy questions on how best to control mumps,” said Dr. Yonatan Grad, assistant professor of immunology and infectious diseases at Harvard Chan School, who co-authored the study with Dr. Joseph Lewnard, postdoctoral research fellow at Harvard Chan School’s Center for Communicable Disease Dynamics. Read more