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Member Research & Reports

Member Research & Reports

Harvard: Sandcastles and Surprising Origins of Basic Cellular Functions

Cells comprising a tissue can pack into disorderly geometries much as do grains of sand in a sandcastle. In doing so they can freeze into a fixed shape — as in a sandcastle — or flow like sand poured from a beach bucket. The finding, reported by researchers at Harvard T.H. Chan School of Public Health, Northeastern University, and MIT, provides insights into organ formation in an embryo, healing of a wound, and even invasion of cells into surrounding tissue, as occurs in cancer.

“This finding makes a deep connection between the physics of inert granular matter such as sand and the geometry of multicellular living systems,” said lead author Dr. Lior Atia, a postdoctoral fellow in the laboratory of Dr. Jeffrey Fredberg, professor of bioengineering and physiology at Harvard Chan School. “Due to the nature of how a cell nestles among its immediate neighbors, a scientist can now look at cell shapes and make a reasonable guess as to why, and how fast, those cells will migrate, remodel, or invade surrounding tissues.”

The study appears online April 2, 2018 in Nature Physics.

Previous work by Dr. Fredberg and colleagues had documented the importance of collective cellular behavior in asthma, showing that cells comprising epithelial tissues — which line the surfaces of all organs throughout the body — can unjam and flow like a fluid, or jam and freeze like a solid.

In the new study, the researchers explored the role of cell shape in two vastly different types of epithelial cells — human bronchial epithelial cells grown in the lab and cells within the living embryo of the fruit fly — and observed them as they matured over time.

As cells jammed or unjammed, cell shapes changed in a systematic manner in both systems, thus suggesting a common physical basis.

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