For women with gestational diabetes mellitus (GDM), triglycerides are significantly elevated throughout pregnancy, according to a review by the University of Iowa College of Public Health’s Dr. Kelli Ryckman, assistant professor of epidemiology, and colleagues.
For the review, published in the January 22 edition of BJOG: An International Journal of Obstetrics and Gynaecology, the researchers conducted a systematic review and meta-analysis to examine the correlation between lipid measures throughout pregnancy and GDM. Data from 60 studies were pooled and random effects models were used to calculate the weighted mean difference (WMD) in lipid levels.
The researchers found that for women with versus those without GDM, triglyceride levels were significantly elevated (WMD, 30.9); this finding was consistent across all trimesters of pregnancy. In women with versus those without GDM, high-density lipoprotein cholesterol levels were significantly lower in the second and third trimesters of pregnancy (WMD, −4.6 and −4.1, respectively). There were no differences seen in aggregate total cholesterol or low-density lipoprotein cholesterol between women with GDM and those without insulin resistance.