Dr. Elizabeth Colantuoni, senior scientist in the department of biostatistics at the Johns Hopkins Bloomberg School of Public Health, has received a four-year, $883,486 grant from the National Institute on Aging. The grant will be used to improve the design and analysis of randomized controlled trials of delirium in critically ill patients and the associated long-term cognitive impairment in older adults.
More than 70 percent of older adults receiving care in U.S. intensive care units (ICUs) experience delirium, which is strongly associated with long-term cognitive impairment that is similar to Alzheimer’s disease and related dementias. A growing number of randomized controlled trials are evaluating interventions to prevent or treat delirium, however, quantifying the effect of these interventions is challenging due to delirium’s fluctuating nature and the competing events of ICU discharge and death.
The research team will review current statistical methodologies applied to delirium randomized controlled trials, develop statistical methods and make recommendations for defining and analyzing delirium as an endpoint in randomized controlled trials of critically ill patients.
Dr. Colantuoni has served as the lead biostatistician for the Outcomes After Critical Illness and Surgery Research Group, based at Johns Hopkins School of Medicine, for 10 years. During this time, she has become an expert in statistical methods for studies of critically ill patients.Tags: Friday Letter Submission