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Member Research and Reports

Member Research and Reports

Kentucky: Statin Users at Higher Risk for Gastrointestinal Hemorrhage

Nearly 70 percent of Americans with cardiovascular disease use statins, which have documented bleeding effects independent of their cholesterol-lowering activities. However, the literature is conflicting regarding the association between statin use and gastrointestinal hemorrhage. Investigators from the University of Kentucky have published new research investigating the risk of gastrointestinal hemorrhage in statin users.

Dr. Daniela C. Moga, associate professor of Pharmacy Practice and Science in the University of Kentucky College of Pharmacy with a joint appointment in University of Kentucky College of Public Health Department of Epidemiology, is the corresponding author of “Statin Use and Gastrointestinal Hemorrhage: A Large Retrospective Cohort Study”, published in the American Journal of Cardiovascular Drugs.  Ms. Ashley I. Martinez, UK College of Pharmacy, is the first author. Dr. Patricia Freeman, associate professor of Pharmacy Practice and Science in the UK College of Pharmacy, is co-author.

Using a retrospective cohort study, the investigators found that in a population of commercially insured subjects aged 30 to 65 years, statin users had a higher risk for gastrointestinal hemorrhage than other chronic medication users. These findings are important when treating patients at a high risk for bleeding events.

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