According to Dr. Hui-Yi Lin, associate professor at the Louisiana State University Health Sciences Center ~ School of Public Health, African American (AA) men have a higher risk of developing prostate cancer (PCa) than White men. Single nucleotide polymorphisms (SNPs) are known to play an important role in developing PCa. The impact of PVT1 and its neighborhood genes (CASC11 and MYC) on PCa risk are getting more attention recently. The interactions among these three genes associated with PCa risk are understudied, especially for AA men.
The objective of the study by Dr. Lin, and collaborators from LSUHSC and Moffitt Cancer Center, was to investigate SNP-SNP interactions in the CASC11-MYC-PVT1 region associated with PCa risk in AA men. They evaluated 205 SNPs using the 2,253 PCa patients and 2,423 controls and applied multi-phase (discovery-validation) design. In addition to SNP individual effects, SNP-SNP interactions were evaluated using the SNP Interaction Pattern Identifier (SIPI), which assesses 45 patterns. Results: Three SNPs (rs9642880, rs16902359, and rs12680047) and 79 SNP-SNP pairs were significantly associated with PCa risk. These two SNPs (rs16902359 and rs9642880) in CASC11 interacted frequently with other SNPs with 56 and 9 pairs, respectively.
The research team identified the novel interaction of CASC11-PVT1, which is the most common gene interactions (70 percent) in the top 79 pairs. Several top SNP interactions have a moderate to large effect size (odds ratio=0.27-0.68) and have a higher prediction power to PCa risk than SNP individual effects. They concluded that novel SNP-SNP interactions in the CASC11-MYC-PVT1 region have a larger impact than SNP individual effects on PCa risk in AA men.Friday Letter Submission