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Member Research and Reports

Michigan Research: Faulty Modeling Studies Led to Overstated Predictions of Ebola Outbreak

Frequently used approaches to understanding and forecasting emerging epidemics — including the West African Ebola outbreak — can lead to big errors that mask their own presence, according to a University of Michigan ecologist and his colleagues.

RohaniP
[Photo: Dr. Pejman Rohani]

“In the early days of the Ebola outbreak, a lot of people got into the forecasting business. They did it using appealingly simple mathematical models, and the result was a series of warnings that alerted the world, quite rightly, to the seriousness of the situation,” said Dr. Aaron King, an associate professor in the U-M department of ecology and evolutionary biology. “But in the end, most of those predictions turned out to be overstated.”

On March 23, exactly one year after it announced there was an Ebola outbreak in Guinea, the World Health Organization released a situation update stating that there had been 24,842 Ebola cases, including 10,299 deaths, to date in Sierra Leone, Liberia, and Guinea.

Last September, the U.S. Centers for Disease Control and Prevention estimated — based on computer modeling — that Liberia and Sierra Leone could see up to 1.4 million Ebola cases by January 2015 if the viral disease kept spreading without effective methods to contain it. Belatedly, the international community stepped up efforts to control the outbreak, and the explosive growth slowed.

“Those predictions proved to be wrong, and it was not only because of the successful intervention in West Africa,” Dr. King said. “It’s also because the methods people were using to make the forecasts were inappropriate.”

In a paper published online March 31 in Proceedings of the Royal Society B, King and his colleagues — including the School of Public Health’s Dr. Pejman Rohani, a professor of epidemiology — suggest several straightforward and inexpensive ways to avoid those pitfalls when the next big infectious disease outbreak strikes. Their suggestions pertain to disease transmission models, sophisticated systems of equations that use data from the early stages of an outbreak to predict how it will unfold.

“It’s just a matter of time before the next outbreak, and we want to make sure that we know how to provide reliable forecasts to guide the public health response when it happens,” Dr. King said.

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