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EPA: New Research Shows that Exposure to Chemicals like BPA Disrupts Microbial Communities in Zebrafish

Bisphenol A (BPA) is an industrial chemical that has been used to make certain plastics and resins since the 1960s. In recent years, science has shown that exposure to BPA and its alternatives can result in possible human health effects. Adverse effects on neurodevelopment, behavior, metabolism, and the immune and cardiovascular systems have been found in human and animal models. As a result, regulators and researchers are interested in learning more about bisphenol chemicals.

New research by EPA scientists used zebrafish to examine the effect of several BPA alternatives on two important developmental health indicators — developmental toxicity and microbiota disruption. For the study, zebrafish were exposed to either BPA or the BPA alternatives Bisphenol AF (BPAF), Bisphenol B (BPB), Bisphenol F (BPF), or Bisphenol S (BPS). Researchers conducted developmental toxicity assessments and each chemical was ranked by its potency for developmental toxicity. Results from these assessments showed that BPAF was the most potent chemical and BPS was the least potent.

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