Dr. Donald Jump, a nutrition professor in Oregon State University’s College of Public Health and Human Sciences, has received a $1.3 million award from the National Institutes of Health’s (NIH) National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) for his project titled “Omega-3 fatty acids and the control of fatty liver disease.”
“Non-alcoholic fatty liver disease (NAFLD) and its progression to non-alcoholic steatohepatitis (NASH) have increased in parallel with central obesity, and its prevalence is anticipated to increase as the obesity epidemic remains unabated,” Dr. Jump says. “Our preclinical studies in mice have established that dietary docosahexaenoic acid (DHA) prevents the onset and blocks the progression of NASH. This application will define the mechanisms for the beneficial effect of DHA on liver health.”
Dr. Jump, who has been funded by NIH and other federal agencies since 1986, has pioneered the study of how dietary fatty acids regulate gene expression, how dietary lipids alter lipid content of the liver, and the efficacy of dietary omega-3 fatty acids to prevent fatty liver disease in rodent models caused by a diet of high-fat, micronutrient deficiencies typical of American and Northern European countries.
The award begins on June 15, and runs through March 31, 2021.Tags: Biostatistics and Informatics, Diet and Nutrition, obesity, Oregon State