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Member Research & Reports

Member Research & Reports

Penn State: Popular Electronic Cigarette May Deliver Nicotine More Effectively Than Others

When it comes to nicotine delivery, not all electronic cigarettes are created equally. According to research from Penn State College of Medicine, JUUL, a pod-based e-cigarette, can deliver more nicotine at a faster rate than most other e-cigarettes that have been studied.

According to Penn State’s Drs. Jessica M. Yingst, Jonathan Foulds and John Richie, previous studies of other e-cigarettes with high liquid nicotine concentrations revealed that many delivered very little nicotine to the user. For this study, researchers profiled the nicotine delivery capabilities of JUUL, which is known to have a high concentration.

JUUL users were asked to puff on their e-cigarettes for 20-second intervals over the course of 10 minutes. Blood samples were collected during and after vaping. The researchers used liquid chromatography and mass spectrometry to analyze the amount of nicotine in the blood at each time point. Participants were asked to rate their withdrawal symptoms and other subjective effects like craving and anxiety both before and after vaping. Participants also completed a questionnaire designed to measure addiction to electronic cigarettes. JUUL users who completed the survey self-reported higher nicotine dependence compared with more than 3,000 experienced long-term users of other electronic cigarettes. The findings were published in JAMA Open Network on Nov. 15.

“The JUUL users we studied obtained blood nicotine concentrations almost three times as high as most of the e-cigarette users we previously studied,” Dr. Yingst said. “JUUL’s nicotine delivery is very similar to that of cigarettes.”

Drs. Shari Hrabovsky, Andrea Hobkirk and Mr Neil Trushin, all of Penn State College of Medicine, also contributed to this research.

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