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Member Research & Reports

Member Research & Reports

Penn State: Study Explores Mortality Rates Associated with Peptic Ulcer Disease and Surgery

“Risk factors of perioperative mortality from complicated peptic ulcer disease (PID) in Africa: Systematic review and meta-analysis,” explores cases where fatalities resulted during post-surgery hospital stays. Experts from Penn State College of Medicine, Penn State University, and Eastern Regional Hospital in Ghana aim to improve treatment options and survival rates for patients suffering from PUD-related complications in 24 sub-Saharan Africa countries.

The team, including PhD in epidemiology student Dr. Paddy Ssentongo and MD/MPH student Ms. Sarah Peiffer, reviewed 95 reports from 1955 to 2018, looking at more than 10,000 patients with PUD complications. Sixty-four percent had a history of peptic ulcers. Medical treatment varied depending on condition. Forty-one percent needed surgery for perforations; 22 percent required surgery for an obstruction within the digestive system.

The review sheds light on specific regions and the complications that need increased interventions to reduce PUD-related deaths. The study shows that, in Africa, the mortality rate from surgical PUD is approximately 6.6 percent and varies by country, with the highest mortality rate in the southern region. Patients who underwent surgery for bleeding and perforated ulcers had the highest risk of death. In addition, older patients are more likely to die from complications of PUD.

The review was recently published by BMJ Open Gastroenterology. Penn State’s Matthew Pelton, Dr. Laura Keeney, Dr. Eustina G Kwon, Dr. David Soybel, Dr. John S. Oh, Dr. Vernon Chinchilli and Dr. Yubraj Acharya also contributed to this project. In addition, the review features Drs. Forster Amponsah and Richard Ofosu-Okromah from Eastern Regional Hospital in Koforidua, Ghana.

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