Women who experience adverse pregnancy outcomes are at an increased risk for future cardiovascular disease, according to a research review led by exercise science assistant professor Dr. Abbi Lane-Cordova at the University of South Carolina Arnold School of Public Health. The paper, which synthesizes the current information and knowledge gaps regarding the progression of adverse pregnancy outcomes to cardiovascular disease in women, is the result of a collaboration between Dr. Lane-Cordova and researchers from Northwestern University. “Long-Term Cardiovascular Risks Associated With Adverse Pregnancy Outcomes” was published in the Journal of the American College of Cardiology as the journal’s review topic of the week.
Adverse pregnancy outcomes are common interrelated disorders caused by placental dysfunction and maternal vascular reaction. They occur in approximately 10 to 20 percent of pregnancies and include problems such as pre-term birth, pre-eclampsia and intrauterine growth restriction. They are associated with an increased risk of cardiovascular disease, particularly hypertension, left ventricular hypertrophy/dysfunction, vascular dysfunction and renal dysfunction.
“The vascular abnormalities that are present during an adverse pregnancy outcome also underlie common, difficult-to-treat forms of cardiovascular disease in women as they age, such as cardiac microvascular dysfunction, heart failure with preserved ejection fraction,” Dr. Lane-Cordova says. “This suggests that adverse pregnancy outcomes and cardiovascular disease share mechanistic pathways.”Friday Letter Submission