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Member Research and Reports

Member Research and Reports

Tulane Researchers Use E.Coli to Make Potential Malaria Vaccine

A Tulane University researcher has found a way to use E.coli bacteria to cheaply manufacture a once hard-to-produce protein critical to the development of a potential transmission-blocking malaria vaccine. Dr. Nirbhay Kumar, professor and chair of tropical medicine at Tulane University School of Public Health and Tropical Medicine, worked with Dr. Evelina Angov of the Walter Reed Army Institute for Research to use the common bacteria to create a new process to purify and refold protein CHrPfs25. When tested as a vaccine, the protein produced a 100 percent effective malaria transmission-blocking antibody response in mice using the two most common species of malaria-carrying mosquitoes, according to results to be published in the April issue of the journal Infection and Immunity.