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Member Research and Reports

Member Research and Reports

UAB: Association of Umbilical Cord Milking vs Delayed Umbilical Cord Clamping With Death or Severe Intraventricular Hemorrhage Among Preterm Infants

Is there a difference in the rates of death or severe intraventricular hemorrhage among preterm infants who receive placental transfusion with umbilical cord milking vs delayed umbilical cord clamping?

Umbilical cord milking as an alternative to delayed umbilical cord clamping may provide equivalent benefits to preterm infants, but without delaying resuscitation. Umbilical cord milking provides a placental transfusion by pushing blood toward the newborn before the umbilical cord is clamped with a duration similar to immediate umbilical cord clamping, allowing the neonatal team to begin resuscitation promptly.  The objective of the current randomized clinical trial was to determine whether umbilical cord milking was noninferior to delayed umbilical cord clamping among preterm infants.

A team of researchers collaborated on this study, including Dr. Jeff Szychowski and Dr. Gary Cutter in the Department of Biostatistics, University of Alabama at Birmingham School of Public Health, .

In this post hoc analysis of a prematurely terminated randomized clinical trial of umbilical cord milking vs delayed umbilical cord clamping among preterm infants born at less than 32 weeks’ gestation, there was no statistically significant difference in the rate of a composite outcome of death or severe intraventricular hemorrhage, but there was a statistically significantly higher rate of severe intraventricular hemorrhage in the umbilical cord milking group. The early study termination and resulting post hoc nature of the analyses preclude definitive conclusions.

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