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Member Research and Reports

Member Research and Reports

UAB Develops New Probabilistic Model for Genotype Calling and Haplotype Phasing

Whole genome sequencing of large population samples is becoming reality for modern genetic epidemiological studies. Sophisticated statistical methods for genotype calling and haplotype phasing are used to model population histories and experimental errors. University of Alabama at Birmingham (UAB) School of Public Health investigators have developed a new method that can increase the length of inferred haplotype blocks by 60 to 80 percent over existing methods. In a recent study published in the journal of Bioinformatics, “Joint Haplotype Phasing and Genotype Calling of Multiple Individuals Using Haplotype Informative Reads,” Dr. Kui Zhang, associate professor in the department of biostatistics, and Dr. Degui Zhi, assistant professor, developed a new probabilistic model for genotype calling and haplotype phasing from next-generation sequencing (NGS) data.