Left ventricular (LV) hypertrophy affects up to 43 percent of African Americans (AAs). Antihypertensive treatment reduces LV mass (LVM). However, interindividual variation in LV traits in response to antihypertensive treatments exists. We hypothesized that genetic variants may modify the association of antihypertensive treatment class with LV traits measured by echocardiography.
A team of researchers, including Drs. Anh Do, Stella Aslibekyan, Hemant Tiwari, and Marguerite (Ryan) Irvin, from the UAB School of Public Health, evaluated the main effects of the three most common antihypertensive treatments for AAs as well as the single nucleotide polymorphism (SNP)‐by‐drug interaction on LVM and relative wall thickness (RWT) in 2,068 participants across five community‐based cohorts. Treatments included thiazide diuretics (TDs), angiotensin converting enzyme inhibitors (ACE‐Is), and dihydropyridine calcium channel blockers (dCCBs) and were compared in a pairwise manner. They performed fixed effects inverse variance weighted meta‐analyses of main effects of drugs and 2.5 million SNP‐by‐drug interaction estimates.
They observed that dCCBs versus TDs were associated with higher LVM after adjusting for covariates, and reported three SNPs at a single locus on chromosome 20 that modified the association between RWT and treatment when comparing dCCBs to ACE‐Is with consistent effects across cohorts. This locus has been linked to LV hypertrophy in a previous study. A marginally significant locus in BICD1 was validated in an external population.
The study identified one locus having genome‐wide significant SNP‐by‐drug interaction effect on RWT among dCCB users in comparison to ACE‐I users.Friday Letter Submission, Publish on August 23