Connect

Member Research and Reports

Member Research and Reports

UAB Monitors Futility in Factorial Designed Study

Investigating different approaches to monitoring futility in two-by-two factorial clinical trials and comparing their properties, Dr. Leslie McClure, and fellow professor Dr. George Howard, in the department of biostatistics at the University of Alabama at Birmingham (UAB) School of Public Health, attempted to fill a gap in the literature by focusing on their experience in the Secondary Prevention of Small Subcortical Strokes (SPS3) Study. SPS3 is a randomized clinical trial with a two-by-two factorial design, employed to examine the effect of both an antiplatelet intervention and blood pressure control on stroke recurrence.