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Member Research & Reports

Member Research & Reports

UAB: Prediabetes and Risk for Cardiovascular Disease by Hypertension Status in Black Adults: The Jackson Heart Study

Recent studies have suggested that prediabetes is associated with an increased risk for cardiovascular disease (CVD) only among individuals with concomitant hypertension.

A team of researchers, including Ms. Demetria Hubbard, Dr. Lisandro Colantonio, Dr. Rikki Tanner, Dr. April Carson, Ms. Swati Sakhuja, doctoral student, Dr. Byron Jaeger, Dr. John Booth, III, and Dr. Paul Muntner, from the University of Alabama at Birmingham School of Public Health, analyzed the association between prediabetes and CVD by hypertension status among 3,313 black adults in the Jackson Heart Study (JHS) without diabetes or a history of CVD at baseline (2000-2004). Prediabetes was defined as fasting plasma glucose between 100 and 125 mg/dL or hemoglobin A1c between 5.7 and 6.4 percent (39 and 46 mmol/mol). Hypertension was defined as systolic/diastolic blood pressure ≥140/90 mmHg and/or self-reported antihypertensive medication use. Participants were followed for incident CVD events and all-cause mortality through 31 December 2014.

Overall, 35 percent of JHS participants did not have prediabetes or hypertension, 18 percent had prediabetes alone, 22 percent had hypertension alone, and 25 percent had both prediabetes and hypertension. Among participants with and without hypertension, there was no association between prediabetes and an increased risk for CVD. No association was present between prediabetes and all-cause mortality among participants with or without hypertension.

The authors concluded that regardless of hypertension status, prediabetes was not associated with an increased risk for CVD or all-cause mortality in this cohort of black adults.

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