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Member Research and Reports

Member Research and Reports

UAB Professor Illustrates the Notion of Confounding by Linkage Disequilibrium

Linkage disequilibrium (the non-random association of genetic variants in a population) and confounding are two widely-discussed concepts in genetics and in epidemiology, yet their relationship has received only intuitive or no considerations. Dr. Brahim Aissani, research assistant professor in the department of epidemiology at the University of Alabama at Birmingham School of Public Health, recently outlined in the Journal of Human Genetics the high potential for confounding in association studies due to linkage disequilibrium (LD), a simple but novel concept that may help understand some of the unexplained but consistently replicated genetic associations.