Dr. Suzanne E. Judd, associate professor in the department of biostatistics at the University of Alabama at Birmingham, collaborated with lead author Dr. Bhupesh Panwar in UAB’s division of nephrology, to examine the connection between concentrations of hemoglobin in the blood and an elevated risk for stroke, noting that previous studies took into account only a comparatively limited number of stroke events.
[Photo: Dr. Suzanne E. Judd]
Using Cox proportional hazards analysis and Kaplan–Meier plots, adjusted for demographic and clinical factors, the researchers investigated Reasons for Geographic and Racial Differences in Stroke (REGARDS) study data pertaining to 518 participants who had experienced incidents of stroke at follow-up. They determined that lowest (<12.4 g/dL) and highest (>14.0 g/dL) quartiles of hemoglobin in the women in their study were linked to an increased probability of incident stroke but found no such association in the men. Comparable outcomes were detected in models classified by hemoglobin and sex, as well as when hemoglobin was a continuous variable.
UAB co-investigators are Dr. David G. Warnock, professor and director, and Dr. Orlando M. Gutiérrez, associate professor, in the division of nephrology; and Mr. John N. Booth III, graduate trainee and PhD candidate, and Dr. Paul Muntner, professor and vice chair, in the department of epidemiology.
“Hemoglobin Concentration and Risk of Incident Stroke in Community-Living Adults” was published online in June in the journal Stroke.