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Member Research and Reports

Member Research and Reports

UAB Researches Mitochondrial DNA Haplogroups in African American Individuals

Dr. Brahim Aissani, research assistant professor in the department of epidemiology at the University of Alabama at Birmingham and department colleagues recently reported on mtDNA diversity in a sample of African American individuals enrolled in a multicenter cohort. The research highlighted the importance of sampling study participants from multicenter cohort to achieve a good representation of the population under study and allow for the generalization of the data. Because mtDNA haplogroups further break down the population composition defined by nuclear markers, which define broad (continental) populations, the study suggested the combined use of mtDNA haplogroups and principal components based on nuclear markers to control for the spurious effects of population structure in genetic association studies.