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Member Research and Reports

Member Research and Reports

UCLA: Lancet Paper Shows Most Popular Hypertension Drug Isn’t Most Effective, Per OHDSI’s LEGEND Study

Thiazide diuretics demonstrate better effectiveness and cause fewer side effects than angiotensin-converting enzyme (ACE) inhibitors as first-line antihypertensive drugs, according to a report published Oct. 24 in The Lancet, for which Dr. Marc A. Suchard, professor of biostatistics at the UCLA Fielding School of Public Health, served as lead author. The study factors insurance claim data and electronic health records from 4.9 million patients across nine observational databases, making it the most comprehensive one ever on first-line antihypertensives, and it provides additional context to the 2017 guidelines for high blood pressure treatment developed by the American College of Cardiology (ACC) and American Heart Association (AHA).

Collaborators in the Observational Health Data Sciences and Informatics (OHDSI) network produced the paper “Comprehensive comparative effectiveness and safety of first-line antihypertensive drug classes: a systematic, multinational, large-scale analysis” as part of the collaborative’s ongoing Large-Scale Evidence Generation and Evaluation across a Network of Databases (LEGEND) project, which applies high-level analytics to perform observational research on hundreds of millions of patient records within OHDSI’s international database network.

OHDSI researchers believe LEGEND will continue to significantly enhance how real-world evidence is used to study important healthcare questions that impact millions of patients worldwide.

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