UCLA researchers have found that commonly used hormone therapies for women diagnosed with breast cancer do not appear to cause significant cognitive dysfunction following the treatment.
Endocrine therapy has become an essential part of treatment for the many women diagnosed with hormone-receptor positive breast cancer, in which hormones, such as estrogen, promote cancer growth. The endocrine treatment helps lower the recurrence and reduce the risk of death from breast cancer by interfering with how a woman’s own hormones can continue to support the growth of dormant cancer cells. Yet, there has been limited evidence on whether this therapy has substantial negative effects on brain function.
The study, published in the journal Cancer, is one of the largest and longest studies to address the question of whether endocrine therapy is associated with cognitive changes. The team followed breast cancer survivors for up to six years and found no cognitive differences over time between breast cancer survivors who received endocrine therapy and those who did not.
“Women are often recommended to stay on this treatment for five to 10 years, so risk to cognitive health can be a big concern,” said lead author Dr. Kathleen Van Dyk, a neuropsychologist at the Semel Institute of Neuroscience and Human Behavior and the UCLA Jonsson Comprehensive Cancer Center. “This study provides some big-picture reassurance for the many women who are taking and will be prescribed these medications; there does not appear to be neuropsychological differences when we compared breast cancer survivors taking endocrine therapy to those who were not.”
To assess the effects of endocrine therapy on neuropsychological function in breast cancer survivors, the UCLA team evaluated 189 early-stage breast cancer survivors before the start of endocrine therapy if indicated, and then followed participants six and 12 months later with neuropsychological assessments. All participants were invited back about three to six years after the start of the study for an extended neuropsychological follow-up, of which 102 women consented to be tested.
The scientists then examined whether neuropsychological performance or impairment rates differed over time based on whether endocrine therapy was prescribed after initial cancer treatments. Contrary to their expectation, the team observed no differences in cognitive function in women one year after completing the treatment or at a subsequent follow-up three to six years later.