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Member Research and Reports

Member Research and Reports

UMiami: Researchers Investigate Epidemiology and Etiology of Leukemia and Lymphoma

Leukemia and lymphoma occur in humans sporadically, but the specific cause of the diseases remain elusive.

To help direct prevention measures, Ms. Jordan Baeker Bispo, Dr. Paulo Pinheiro, and Dr. Erin K. Kobetz from the Miller School of Medicine co-authored a paper, published in the Cold Spring Harbor Perspectives in Medicine, that analyzed the etiology and epidemiology of the diseases.

They analyzed four types of pediatric and adult leukemias and two types of lymphomas – acute myeloid leukemia, acute lymphocytic leukemia (ALL), chronic myeloid leukemia, chronic lymphocytic/small cell lymphoma, non-Hodgkin’s lymphoma, and Hodgkin’s lymphoma.

Incidence appears to be highest in highly developed regions across Europe, Northern America, and Australia, and among Whites in the United States. ALL is an exception to this, as its incidence is highest in South and Central American countries and among Hispanics in the U.S.

Prognosis varies by subtype. Researchers found that there are poorer survival outcomes for acute leukemias among adults, and more favorable outcomes for Hodgkin’s lymphoma.

Temporal trends in hematologic malignancies are dynamic and sometimes unpredictable, as demonstrated by a large global increase in non-Hodgkin’s lymphoma incidence around the turn of the century, because of the human immunodeficiency virus (HIV) epidemic and the increasing number of transplants performed in the developed countries.

“At a time when specific prevention targeting these malignancies is nonexistent, there is a great need to ensure equitable access to diagnostic services and treatments worldwide,” researchers noted.

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