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Member Research and Reports

Member Research and Reports

UNC Study Explores Impact of Glucose Uptake on Inflammatory Processes Related to Obesity

A recent study by researchers at the University of North Carolina Gillings School of Global Public Health provides insight into the biochemical processes through which increased sugar intake may play an integral role in the promotion of obesity-related insulin resistance. The study’s senior author was Dr. Liza Makowski, assistant professor of nutrition at the Gillings School and member of the UNC Lineberger Comprehensive Cancer Center. In a cell culture study with supportive data from rodents which were made obese by a high-fat diet, Dr. Makowski and colleagues demonstrated that elevated glucose metabolism through increased glucose transporter, called GLUT1, drives the inflammation of macrophages, the large white blood cells in tissue that ingest and engulf foreign particles, dying cells, and infectious microorganisms.