A study of more than 6,000 first-graders across four United States communities has found that a significant number of the children have fetal alcohol spectrum disorders (FASD). Published Feb. 6 in the Journal of the American Medical Association (JAMA), the study was co-led by Dr. Philip A. May, research professor of nutrition at the University of North Carolina Gillings School of Global Public Health. Dr. May is based at the UNC Nutrition Research Institute in Kannapolis, NC.
[Photo: A study of more than 6,000 first-graders across four U.S. communities has found that a significant number of the children have fetal alcohol spectrum disorders. Photo by Joe Shlabotnik]
FASD is an umbrella term for a range of health effects caused by prenatal alcohol exposure. Individuals with FASD may experience growth deficiencies, facial abnormalities and organ damage, including to the brain. The effects of prenatal alcohol exposure on the brain can result in a range of neurobiological deficits that contribute to physical, cognitive, behavioral and social challenges throughout life.
The research effort, funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), part of the National Institutes of Health, found conservative rates of FASD ranging from 1 percent to 5 percent in community samples. The new findings represent more accurate prevalence estimates of FASD among general U.S. communities than has prior research. Previous FASD estimates were based upon smaller study populations and did not reflect the overall U.S. population.
“Prenatal alcohol exposure is a leading preventable cause of developmental disabilities worldwide,” said NIAAA Director Dr. George F. Koob. “Estimating the prevalence of FASD in the U.S. has been complex due to the challenges in identifying prenatally exposed children. The findings of this study confirm that FASD is a significant public health problem, and strategies to expand screening, diagnosis, prevention and treatment are needed to address it.”
The study was conducted by the Collaboration on Fetal Alcohol Spectrum Disorders Prevalence (CoFASP) consortium, which studies the prevalence of FASD among U.S. school children. Before the study began, consortium members established standardized classification criteria for FASD based on facial features, growth and neurodevelopmental performance.
Researchers collected data between 2010 and 2016 on 6,639 children in four communities in the Midwest, Rocky Mountain, Southeast and Pacific Southwest, sites that were selected to be more reflective of U.S. community populations than previous studies. At each site, first-graders in public and private schools were recruited across two academic years and evaluated based on the FASD criteria. Prenatal alcohol exposure was assessed by interviewing mothers or other close relatives.
The researchers found that the prevalence estimates for FASD among the selected sites ranged from 1.1 to 5 percent. This was the most conservative estimate and assumed that no additional cases of FASD would be found in first-graders who did not participate in the study.
Using a “weighted prevalence” approach that assumed that the rate of FASD in children who were evaluated would be the same in all eligible first-grade children in each community, the estimated prevalence of FASD was higher — ranging from 3.1 to 9.8 percent among the study sites. Of the 222 children diagnosed with FASD in the study, only two had been previously diagnosed with FASD, although many parents and guardians were aware of the children’s learning and behavioral challenges. This finding suggests that children with FASD often go undiagnosed or misdiagnosed.
“We believe our study is the first to use school-based assessments, a common methodology and classification system, and expert in-person evaluations for the full range of FASD on many children from communities across the United States,” Dr. May said.
Dr. Christina Chambers, a perinatal epidemiologist and professor of pediatrics in the University of California at San Diego’s School of Medicine, was co-principal investigator for the research and co-author of the published study.