The National Institute of Environmental Health Sciences (NIEHS) selected University at Buffalo research as an Extramural Paper of the Month. According to NIEHS, each paper of the month is selected “based on their important findings and potential for public health impact.”
The paper, “Multi-generational impacts of arsenic exposure on genome-wide DNA methylation and the implications for arsenic-induced skin lesions,” was originally published in Environment International by Dr. Xuefeng Ren of the department of epidemiology and environmental health. Dr. Ren and colleagues found that arsenic exposure affected DNA methylation in similar ways regardless of when during life the exposure occurred, that the changes persisted for decades and potentially were inherited across generations. They found that the aberrant DNA methylation was enriched in patients with arsenic-induced skin lesions.
In addition to Dr. Ren, contributing University at Buffalo co-authors include Mr. Xushen Chen, department of epidemiology and environmental health, School of Public Health and Health Professions; Dr. Jie Wang, department of biochemistry, Jacobs School of Medicine and Biomedical Sciences; and Drs. Daniel Gaile and Guan Yu, department of biostatistics, School of Public Health and Health Professions.
Dr. Xiaojuan Guo, the study’s lead author, is from the School of Public Health, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China.