The National Institutes of Health (NIH) and National Institute of General Medical Sciences (NIGMS) awarded Dr. Mayur Patel, assistant professor of Surgery, Neurosurgery and Hearing and Speech Sciences, a $3 million, five-year grant to advance his study on cognitive impairment after trauma and critical illness (Grant No. R01 GM120484).
Patel’s INSIGHT-ICU Study: Illuminating Neuropsychological Dysfunction and Systemic Inflammatory Mechanisms Gleaned after Hospitalization in Trauma-ICU, will enroll 900 trauma intensive care unit patients, with and without traumatic brain injury (TBI).
Dr. E. Wes Ely, professor of Medicine, and Dr. Pratik Pandharipande, professor of Anesthesiology and Surgery, in VUMC’s ICU and Cognitive Impairment Study Group, are co-investigators on this study, which is the first federally funded TBI study at VUMC. Other co-investigators include Dr. James Jackson; Dr. Christopher Hughes; Dr. Julie Bastarache; Dr. Rameela Chandrasekhar; Dr. Colin McKnight; and Dr. Bennett Landman; and researchers from Loyola University and Johns Hopkins University.
Driving this proposal’s success was key pilot data supported by the Vanderbilt Institute in Surgery and Engineering (VISE), the Vanderbilt Center for Quantitative Sciences (CQS), the Robert J. Kleberg Jr. and Helen C. Kleberg Foundation, and a grant-studio from Vanderbilt Institute for Clinical and Translational Research (VICTR, VR16305).
“This study moves our group’s cutting-edge work on long-term cognitive impairment after critical illness into the challenges of trauma and superimposed complexities of TBI,” Pandharipande said.
Dr. John Morris, Associate Chief of Staff, professor of Surgery and former Chief of Trauma, said, “In more than 30 years of our Trauma Division, we have done many remarkable things, but Dr. Patel is the first at his level to lead us in the arena of federally funded trauma and TBI research.”