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Member Research and Reports

Member Research and Reports

Vanderbilt-led Study Finds Significant Drop in New Prostate Cancer Diagnoses

A new study led by Vanderbilt University Medical Center investigators found new diagnoses of prostate cancer in the U.S. declined 28 percent in the year following the draft recommendation from the United States Preventive Services Task Force (USPSTF) against routine PSA screening for men.

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[Photo: Dr. Daniel Barocas]

The new research, led by first author Dr. Daniel Barocas, assistant professor of Urological Surgery and Medicine, was posted online in the June 15 issue of The Journal of Urology in advance of publication.

In October 2011, the USPSTF issued a draft guideline discouraging the use of prostate-specific antigen (PSA)-based screenings for prostate cancer after concluding the harms outweigh potential benefits. Harmful side effects of treatment may include incontinence, erectile dysfunction, and radiation cystitis.

However, the recommendation was considered controversial because of uncertainty about the risks and benefits of screening since prostate cancer is the second leading cause of cancer death among men in the U.S., with nearly 30,000 deaths annually, and some studies show that screening saves lives.

The research revealed that 12 months after the draft USPSTF guidelines were published diagnoses of new low-risk cancers had fallen by 37.9 percent while colon cancer cases remained stable.

New prostate cancer diagnoses also declined by 23 to 29.3 percent among men over age 70 and 26 percent among men considered infirm. The authors note these are populations who are unlikely to live long enough to benefit from early detection and are at risk of harms of treatment.

However, the investigators suggest that withholding screening may also result in failure to detect higher-risk cancers during the window of curability. Timely treatment of intermediate and high-risk localized disease is associated with superior overall survival, disease-specific survival, and decreased spread of the disease to other locations in the body.

The study identified a drop of 28.1 percent in diagnoses of intermediate-risk disease and 23.1 percent in high-risk prostate cancer one year after the draft guideline.

“The results raise concern that if this trend continues more men may be diagnosed at a point when their disease is advanced. Younger, healthier men with intermediate or high-risk disease would normally be candidates for aggressive local therapy and they may not be receiving a timely diagnosis under this policy,” said Barocas.

The authors suggest that future research should focus on screening regimens that minimize harms and maximize potential benefits of screening, while also considering patient preferences.

Other investigators participating in the study include Ms. Amy Graves and Drs. David Penson and Sam Chang from Vanderbilt, and Mr. Bryan Palis and Drs. Katherine Mallin and David Winchester from the National Cancer Database, American College of Surgeons, Chicago.

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