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Member Research & Reports

Member Research & Reports

Washington: Infection History May Hold Key to Designing Better Dengue Vaccines

Researchers have known for some time that being infected with one of the four dengue serotypes provides long-term immunity against that particular strain, and short-term immunity against the other three. But precisely how previous infection affects the risk of subsequent infection was not clear.

Now, new research examined how a child’s first dengue virus infection impacts the risk of future infection and found that, compared to children never infected with the dengue virus, children with one prior infection had a lower risk of new infection. Children with two or more infections experienced a higher risk of new infection.

Dr. Elizabeth Halloran, a professor of biostatistics at the University of Washington School of Public Health, co-authored this study, which introduces a new statistical method to infer full infection history for dengue. Dr. Halloran played a key role in the development of these methodologies.

The study utilized data from a pediatric cohort in Nicaragua to modulate the risks of dengue virus infection and subsequent clinical disease.

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