Wound healing events in mucous tissues during early infection by Simian Immunodeficiency Virus, or SIV, guard some primate species against developing acquired immune deficiency syndrome (AIDS), according to a multi-institutional study led in part by Dr. Michael Gale, Jr., professor of immunology and adjunct professor of global health at the University of Washington Schools of Public Health and Medicine.
The research looked at why certain species can carry the virus throughout their lives, and still avoid disease progression. SIV is closely related to the Human Immunodeficiency Virus. It is used as a laboratory model for many studies seeking AIDS and human immunodeficiency virus (HIV) cures and preventions.
In this latest study, reported in Nature Communications, scientists sought to uncover, in natural hosts, successful virus-fighting tactics that could inform the design of better antiviral drugs to treat HIV in people. They found that the biological events involved in wound healing of mucosal tissues create an environment inside the body that protects against the destructive consequences of SIV infection. Aspects of this wound-healing immune response could become targets for developing new therapies to prevent AIDS in people with HIV infections.Friday Letter Submission, Publish on January 10